PMID- 24055400
OWN - NLM
STAT- MEDLINE
DCOM- 20141117
LR  - 20220409
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 68
IP  - 2
DP  - 2014 Mar
TI  - miR-370 targeted FoxM1 functions as a tumor suppressor in laryngeal squamous cell 
      carcinoma (LSCC).
PG  - 149-54
LID - S0753-3322(13)00097-8 [pii]
LID - 10.1016/j.biopha.2013.08.008 [doi]
AB  - microRNAs, a family of small non-coding RNAs, involve in the pathogenesis of 
      several types of cancers, including laryngeal squamous cell carcinoma (LSCC). 
      MiR-370 is frequently aberrant expressed in various types of human cancer 
      including LSCC. However, the role for miR-370 in LSCC remains elusive. Here, we 
      demonstrate that miR-370 was down-regulated in human LSCC tissues. Furthermore, 
      there was an inverse relationship between Forkhead Box ml (FoxM1), which was 
      up-regulated and miR-370 expression in LSCC tissues. FoxM1 was subsequently 
      predicted by bioinformatics and verified to be a target of miR-370 by Luciferase 
      reporter assay. Restored expression of miR-370 in Hep2 cells significantly 
      inhibited cell proliferation. In conclusion, our results suggest that miR-370 may 
      function as a tumor suppressor in LSCC through downregulation of FoxM1, 
      suggesting that miR-370 could serve as a novel potential maker for LSCC therapy.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Yungang, Wu
AU  - Yungang W
AD  - Department of Otolaryngology-Head and Neck Surgery, Qi-Lu Hospital, Shandong 
      University, Jinan, Shandong Province, PR China; Department of Otolaryngology-Head 
      and Neck Surgery, the Affiliated Hospital of Jining Medical University, Jining, 
      Shandong Province, PR China.
FAU - Xiaoyu, Li
AU  - Xiaoyu L
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Jining Medical University, Jining, Shandong Province, PR China.
FAU - Pang, Taizhong
AU  - Pang T
AD  - Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of 
      Jining Medical University, Jining, Shandong Province, PR China.
FAU - Wenming, Li
AU  - Wenming L
AD  - Department of Otolaryngology-Head and Neck Surgery, Qi-Lu Hospital, Shandong 
      University, Jinan, Shandong Province, PR China.
FAU - Pan, Xinliang
AU  - Pan X
AD  - Department of Otolaryngology-Head and Neck Surgery, Qi-Lu Hospital, Shandong 
      University, Jinan, Shandong Province, PR China. Electronic address: 
      panxinliang0531@sina.com.
LA  - eng
PT  - Journal Article
DEP - 20130823
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (FOXM1 protein, human)
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (MIRN370 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - EC 1.13.12.5 (Luciferases, Renilla)
SB  - IM
MH  - Base Sequence
MH  - Binding Sites
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Cell Culture Techniques
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Down-Regulation
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors/*genetics
MH  - Genes, Reporter
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - Luciferases, Renilla/genetics
MH  - MicroRNAs/*genetics
MH  - Molecular Sequence Data
MH  - Plasmids
MH  - Transfection
MH  - Up-Regulation
OTO - NOTNLM
OT  - Cell proliferation
OT  - FoxM1
OT  - Laryngeal squamous cell carcinoma
OT  - MiR-370
EDAT- 2013/09/24 06:00
MHDA- 2014/11/18 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/07/22 00:00 [received]
PHST- 2013/08/10 00:00 [accepted]
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/11/18 06:00 [medline]
AID - S0753-3322(13)00097-8 [pii]
AID - 10.1016/j.biopha.2013.08.008 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2014 Mar;68(2):149-54. doi: 10.1016/j.biopha.2013.08.008. 
      Epub 2013 Aug 23.