PMID- 24055485
OWN - NLM
STAT- MEDLINE
DCOM- 20131224
LR  - 20220316
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 532
IP  - 2
DP  - 2013 Dec 15
TI  - Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and 
      serum adiponectin levels in south Indian population.
PG  - 253-62
LID - S0378-1119(13)01186-4 [pii]
LID - 10.1016/j.gene.2013.09.012 [doi]
AB  - OBJECTIVE: To investigate the genetic association of eight variants of the 
      adiponectin gene with type 2 diabetes mellitus (T2DM), obesity and serum 
      adiponectin level in the south Indian population. METHODS: The study comprised of 
      1100 normal glucose tolerant (NGT) and 1100 type 2 diabetic, unrelated subjects 
      randomly selected from the Chennai Urban Rural Epidemiology Study (CURES), in 
      southern India. Fasting serum adiponectin levels were measured by 
      radioimmunoassay. The variants were screened by polymerase chain 
      reaction-restriction fragment length polymorphism. Linkage disequilibrium was 
      estimated from the estimates of haplotype frequencies. RESULTS: Of the 8 
      variants, four SNPs namely, +276 G/T (rs1501299), -4522 C/T (rs822393), -11365 
      C/G (rs266729), and +712 G/A (rs3774261) were significantly associated with T2DM 
      in our study population. The -3971 A/G (rs822396) and -11391 G/A (rs17300539) 
      SNPs' association with T2DM diabetes was mediated through obesity (where the 
      association with type 2 diabetes was lost after adjusting for BMI). There was an 
      independent association of +276 G/T (rs1501299) and -3971 A/G (rs822396) SNPs 
      with generalized obesity and +349 A/G (rs2241767) with central obesity. Four 
      SNPs, -3971 A/G (rs822396), +276 G/T (rs1501299), -4522 C/T (rs822393) and Y111H 
      T/C (rs17366743) were significantly associated with hypoadiponectinemia. The 
      haplotypes GCCATGAAT and AGCGTGGGT conferred lower risk of T2DM in this south 
      Indian population. CONCLUSION: The adiponectin gene variants and haplotype 
      contribute to the genetic risk towards the development of type 2 diabetes, 
      obesity and hypoadiponectinemia in the south Indian population.
CI  - (c) 2013.
FAU - Ramya, Kandaswamy
AU  - Ramya K
AD  - Madras Diabetes Research Foundation-ICMR Advanced Centre for Genomics of Type 2 
      Diabetes and Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai 
      600086, India.
FAU - Ayyappa, Kuppuswamy Ashok
AU  - Ayyappa KA
FAU - Ghosh, Saurabh
AU  - Ghosh S
FAU - Mohan, Viswanathan
AU  - Mohan V
FAU - Radha, Venkatesan
AU  - Radha V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130918
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/blood/*genetics
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Haplotypes
MH  - Humans
MH  - India
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Obesity, Abdominal/blood/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Quantitative Trait, Heritable
MH  - Risk Factors
MH  - Sequence Analysis, DNA
OTO - NOTNLM
OT  - ADIPOQ
OT  - Adiponectin
OT  - Adiponectin gene
OT  - BMI
OT  - Body Mass Index
OT  - HWE
OT  - Hardy-Weinberg Equilibrium
OT  - Hypoadiponectinemia
OT  - LD
OT  - Linkage Disequilibrium
OT  - Obesity
OT  - SNP
OT  - Single Nucleotide Polymorphism
OT  - South Indians
OT  - T2DM
OT  - Type 2 Diabetes Mellitus
EDAT- 2013/09/24 06:00
MHDA- 2013/12/25 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/05/07 00:00 [received]
PHST- 2013/08/28 00:00 [revised]
PHST- 2013/09/04 00:00 [accepted]
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2013/12/25 06:00 [medline]
AID - S0378-1119(13)01186-4 [pii]
AID - 10.1016/j.gene.2013.09.012 [doi]
PST - ppublish
SO  - Gene. 2013 Dec 15;532(2):253-62. doi: 10.1016/j.gene.2013.09.012. Epub 2013 Sep 
      18.