PMID- 24055685
OWN - NLM
STAT- MEDLINE
DCOM- 20140811
LR  - 20221207
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 106
DP  - 2013 Nov
TI  - Synergy effects of HbA1c and variants of APOE and BDNFVal66Met explains 
      individual differences in memory performance.
PG  - 274-82
LID - S1074-7427(13)00176-7 [pii]
LID - 10.1016/j.nlm.2013.08.017 [doi]
AB  - We aimed at exploring if synergy effects of Brain-Derived Neurotrophic Factor 
      (BDNF) Val(66)Met, Apolipoprotein E (APOE) and HbA1c (glycated haemoglobin) could 
      explain individual differences in memory performance over 10 years in a 
      population based sample of nondemented adults (N=888, 35-85 years at baseline). 
      Episodic memory was affected by such agents, wheras semantic memory was spared. 
      Both age and HbA1c were associated with episodic memory decline. BDNF(66)Met 
      carriers with higher HbA1c levels evidenced slope decline in episodic recall. We 
      found support for joint effects of BDNFVal(66)MetxAPOExHbA1c and 
      BDNFVal(66)MetxAPOExage on rates of episodic memory change over ten years, after 
      controlling for age, sex, education and cardiovascular diseases. We conclude that 
      variants of genetic polymorphisms act in synergy with long-term blood glucose 
      control in shaping patterns of cognitive aging.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Persson, N
AU  - Persson N
AD  - Department of Psychology, Stockholm University, Sweden; Institute of Gerontology, 
      Wayne State University, Detroit, MI, USA; Stockholm Brain Institute, Karolinska 
      Institutet, Stockholm, Sweden. Electronic address: 
      ninni.persson@psychology.su.se.
FAU - Lavebratt, C
AU  - Lavebratt C
FAU - Wahlin, A
AU  - Wahlin A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130918
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Apolipoproteins E)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Apolipoproteins E/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Glycated Hemoglobin/*genetics
MH  - Humans
MH  - *Individuality
MH  - Male
MH  - Memory/*physiology
MH  - Memory, Episodic
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - APOE
OT  - Aging
OT  - BDNF
OT  - Episodic memory
OT  - Epistasis
OT  - HbA1c
EDAT- 2013/09/24 06:00
MHDA- 2014/08/12 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/01/25 00:00 [received]
PHST- 2013/08/28 00:00 [revised]
PHST- 2013/08/30 00:00 [accepted]
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/08/12 06:00 [medline]
AID - S1074-7427(13)00176-7 [pii]
AID - 10.1016/j.nlm.2013.08.017 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2013 Nov;106:274-82. doi: 10.1016/j.nlm.2013.08.017. Epub 
      2013 Sep 18.