PMID- 24057189
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 40
IP  - 12
DP  - 2013 Dec
TI  - Polymorphisms of the bovine DKK2 and their associations with body measurement 
      traits and meat quality traits in Qinchuan cattle.
PG  - 6831-5
LID - 10.1007/s11033-013-2800-3 [doi]
AB  - The objective of this research were to detect bovine Dickkopf 2 (DKK2) gene 
      polymorphism and analyze their associations with body measurement traits (BMT) 
      and meat quality traits (MQT) of animals. Blood samples were taken from a total 
      of 541 Qinchuan cattle aged from 18 to 24 months. Polymerase chain 
      reaction-single strand conformation polymorphism (PCR-SSCP) was employed to find 
      out DKK2 single-polymorphism nucleotide (SNPs) and to explore their possible 
      association with BMT and MQT. Sequence analysis of DKK2 gene revealed 2 SNPs (C29 
      T and A169C) in 5' untranslated region (5'UTR) of exon 1.C29T and A164T SNPs are 
      both synonymous mutation, which showed 2 genotypes namely (CC, CT) and (AA and 
      AC), respectively. Association analysis of polymorphism with body measurement and 
      meat quality traits at the two locus showed that there were significant effects 
      on CT, BL, RL, PBW, BFT, LMA, and IFC. These results suggest that the DKK2 gene 
      might have potential effects on BMT and MQT in Qinchuan cattle population and 
      could be used for marker-assisted selection.
FAU - Zhan, Xiaoli
AU  - Zhan X
AD  - College of Animal Science and Technology, Northwest A&F University, Yangling, 
      Shaanxi, People's Republic of China.
FAU - Gao, Jianbin
AU  - Gao J
FAU - Huangfu, Yifan
AU  - Huangfu Y
FAU - Fu, Changzhen
AU  - Fu C
FAU - Zan, Linsen
AU  - Zan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130921
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (5' Untranslated Regions)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - 5' Untranslated Regions/genetics
MH  - Animals
MH  - Base Pairing/genetics
MH  - Base Sequence
MH  - Body Weight/*genetics
MH  - Cattle/*genetics
MH  - Chi-Square Distribution
MH  - China
MH  - Exons/genetics
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - Genetic Loci
MH  - Genetics, Population
MH  - Intercellular Signaling Peptides and Proteins/*genetics
MH  - Meat/*standards
MH  - Molecular Sequence Data
MH  - Mutation/genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Polymorphism, Single-Stranded Conformational
MH  - *Quantitative Trait, Heritable
MH  - Sequence Analysis, DNA
EDAT- 2013/09/24 06:00
MHDA- 2014/07/06 06:00
CRDT- 2013/09/24 06:00
PHST- 2012/12/17 00:00 [received]
PHST- 2013/09/15 00:00 [accepted]
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 10.1007/s11033-013-2800-3 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2013 Dec;40(12):6831-5. doi: 10.1007/s11033-013-2800-3. Epub 2013 
      Sep 21.