PMID- 24057222
OWN - NLM
STAT- MEDLINE
DCOM- 20140730
LR  - 20131217
IS  - 1552-4175 (Electronic)
IS  - 1099-8004 (Linking)
VI  - 16
IP  - 1
DP  - 2014 Jan
TI  - Characterizing activity and muscle atrophy changes in rats with neuropathic pain: 
      a pilot study.
PG  - 16-22
LID - 10.1177/1099800413502722 [doi]
AB  - The study of neuropathic pain has focused on changes within the nervous system, 
      but little research has described systemic changes that may accompany neuropathic 
      pain. OBJECTIVE: As part of a larger project characterizing the metabolic, 
      activity, and musculoskeletal changes associated with neuropathic pain, the 
      objective of the current study was to characterize changes in spontaneous 
      activity and skeletal muscle mass using an established animal model of 
      neuropathic pain, the chronic constriction injury (CCI) model. METHOD: Male 
      Sprague-Dawley rats were used in this pre- and posttest quasi-experimental study. 
      The experimental group (n = 13) received CCI surgery, while age- and 
      weight-matched rats received sham surgery (SHAM; n = 5). Thermal testing verified 
      the presence of neuropathic pain. Spontaneous cage activity was measured 
      gravimetrically prior to and following CCI (n = 4). Animals were euthanized and 
      skeletal muscle was dissected and weighed to determine muscle atrophy. RESULTS: 
      Shorter foot withdrawal latency of the ipsilateral hind limb confirmed the 
      presence of thermal hyperalgesia in CCI rats, a sign of neuropathic pain. Weight 
      increased in both CCI and SHAM rats. Spontaneous activity decreased following CCI 
      ligation. Muscles of the ipsilateral hind limb weighed significantly less than 
      contralateral hind limb muscles in CCI rats 2 and 6 weeks after surgery. In 
      addition, CCI rats had smaller ipsilateral hind limb muscles than SHAM rats. 
      CONCLUSION: Neuropathic pain contributes to skeletal muscle atrophy and decreases 
      in activity in rats.
FAU - Moes, Jesse R
AU  - Moes JR
AD  - 1Department of Nursing, Calvin College, Grand Rapids, MI, USA.
FAU - Holden, Janean E
AU  - Holden JE
LA  - eng
GR  - NR004778/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130919
PL  - United States
TA  - Biol Res Nurs
JT  - Biological research for nursing
JID - 9815758
SB  - IM
MH  - Animals
MH  - Male
MH  - *Muscular Atrophy
MH  - Neuralgia/*physiopathology
MH  - Pilot Projects
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - activity
OT  - muscle atrophy
OT  - neuropathic pain
EDAT- 2013/09/24 06:00
MHDA- 2014/07/31 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/07/31 06:00 [medline]
AID - 1099800413502722 [pii]
AID - 10.1177/1099800413502722 [doi]
PST - ppublish
SO  - Biol Res Nurs. 2014 Jan;16(1):16-22. doi: 10.1177/1099800413502722. Epub 2013 Sep 
      19.