PMID- 24057659
OWN - NLM
STAT- MEDLINE
DCOM- 20151027
LR  - 20220321
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 25
IP  - 3
DP  - 2015 Mar
TI  - Early visuomotor integration processes induce LTP/LTD-like plasticity in the 
      human motor cortex.
PG  - 703-12
LID - 10.1093/cercor/bht264 [doi]
AB  - To investigate whether visuomotor integration processes induce long-term 
      potentiation (LTP) and depression (LTD)-like plasticity in the primary motor 
      cortex (M1), we designed a new paired associative stimulation (PAS) protocol 
      coupling left primary visual area (V1) activation achieved by hemifield visual 
      evoked potentials (VEPs) and transcranial magnetic stimulation (TMS) over the 
      left M1, at specific interstimulus intervals (ISIs), delivered at 1 Hz (V-PAS). 
      Before and after V-PAS, we measured motor evoked potentials (MEPs). To clarify 
      the mechanisms underlying V-PAS, we tested the effect of 1-Hz repetitive TMS 
      (rTMS), 0.25-Hz V-PAS and rTMS, and a shorter 0.25-Hz V-PAS protocol. To examine 
      V-PAS with contralateral V1 activation, we delivered V-PAS activating the right 
      V1. To clarify whether V-PAS increases V1 activity or parieto- and premotor-to-M1 
      connectivity, before and after V-PAS, we examined VEPs and MEPs evoked by 
      paired-pulse techniques. V-PAS increased, decreased, or left MEPs unchanged 
      according to the ISI used. After 1-Hz rTMS MEPs decreased. Although 0.25-Hz rTMS 
      elicited no aftereffect, 0.25-Hz V-PAS modulated MEPs according to the ISI used. 
      The short 0.25-Hz V-PAS protocol left MEPs unchanged. Contralateral V-PAS 
      inhibited MEPs. After V-PAS, VEPs remained unchanged and the premotor-to-M1 
      inhibitory connections decreased. V-PAS induces M1 LTP/LTD-like plasticity by 
      activating premotor-to-motor connections.
CI  - (c) The Author 2013. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Suppa, A
AU  - Suppa A
AD  - IRCCS Neuromed Institute, Pozzilli (IS), Italy.
FAU - Li Voti, P
AU  - Li Voti P
AD  - IRCCS Neuromed Institute, Pozzilli (IS), Italy.
FAU - Rocchi, L
AU  - Rocchi L
AD  - Department of Neurology and Psychiatry.
FAU - Papazachariadis, O
AU  - Papazachariadis O
AD  - Department of Physiology and Pharmacology, "Sapienza" University of Rome, 00185 
      Rome, Italy.
FAU - Berardelli, A
AU  - Berardelli A
AD  - IRCCS Neuromed Institute, Pozzilli (IS), Italy Department of Neurology and 
      Psychiatry.
LA  - eng
PT  - Journal Article
DEP - 20130920
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor
MH  - Evoked Potentials, Visual
MH  - Female
MH  - Humans
MH  - *Long-Term Potentiation
MH  - *Long-Term Synaptic Depression
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Transcranial Magnetic Stimulation
MH  - Visual Cortex/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - paired associative stimulation
OT  - primary motor cortex
OT  - rTMS
OT  - visual evoked potentials
OT  - visuomotor integration
EDAT- 2013/09/24 06:00
MHDA- 2015/10/28 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2015/10/28 06:00 [medline]
AID - bht264 [pii]
AID - 10.1093/cercor/bht264 [doi]
PST - ppublish
SO  - Cereb Cortex. 2015 Mar;25(3):703-12. doi: 10.1093/cercor/bht264. Epub 2013 Sep 
      20.