PMID- 24057858
OWN - NLM
STAT- MEDLINE
DCOM- 20140708
LR  - 20211021
IS  - 1573-7446 (Electronic)
IS  - 0165-7380 (Linking)
VI  - 38
IP  - 1
DP  - 2014 Mar
TI  - Expressions of tumor necrosis factor-alpha, its receptor I, II and 
      receptor-associated factor 2 in the porcine corpus luteum during the estrous 
      cycle and early pregnancy.
PG  - 1-10
LID - 10.1007/s11259-013-9575-9 [doi]
AB  - We examined the gene and protein levels of tumor necrosis factor (TNF)-alpha, its 
      receptors (types I and II, designated TNF-RI and TNF-RII, respectively), TNF 
      receptor-associated factor 2 (TRAF2) and morphological features in the porcine 
      corpus luteum (CL), on Days 13 and 17 (Day 0 = the last day of estrus) of the 
      estrous cycle or of early pregnancy. Gene expression levels of TNF-alpha, TNF-RI, 
      TNF-RII and TRAF2 were unaffected by the day or reproductive status. TNF-alpha 
      concentration was significantly higher in the CL on Day 17 of pregnancy than on 
      Day 13 of pregnancy and on day 17 of the estrous cycle. The TNF-RI protein level 
      was significantly higher in the CL on Days 13 and 17 of pregnancy than those of 
      the estrous cycle, significantly increasing on Day 17 compared with those on Day 
      13 in pregnancy. In relation to TNF-RII protein levels, although there were no 
      change during pregnancy, there was a tendency (P = 0.0524) to up-regulate as 
      pregnancy proceeded. In estrous cycle, TNF-RII protein levels decreased 
      significantly as luteolysis proceeded. TRAF2 protein level was significantly 
      higher in the CL on Days 13 and 17 of pregnancy than during estrous. There were 
      few apoptotic bodies in the CL between Days 13 and 17 of pregnancy than during 
      esrous. There were few apoptotic bodies in the CL between Days 13 and 17 of 
      pregnancy. The number of apoptotic bodies was much greater than the CL on Day 17 
      of the estrous than those of pregnancy. Thus, the TNF-alpha and TNF-RI and TNF-RII 
      pathways including the TRAF2 protein, known to control of cell differentiation, 
      tissue renewal and apoptosis, might participate in maintaining the porcine CL 
      during early pregnancy.
FAU - Suzuki, Chie
AU  - Suzuki C
AD  - Pathology and Pathophysiology Research Division, National Institute of Animal 
      Health, Ibaraki, 305-0856, Japan, schie@affrc.go.jp.
FAU - Yoshioka, Koji
AU  - Yoshioka K
FAU - Yamada, Manabu
AU  - Yamada M
FAU - Miyamoto, Toru
AU  - Miyamoto T
FAU - Manabe, Noboru
AU  - Manabe N
LA  - eng
PT  - Journal Article
DEP - 20130922
PL  - Switzerland
TA  - Vet Res Commun
JT  - Veterinary research communications
JID - 8100520
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Corpus Luteum/*metabolism
MH  - Estrous Cycle/*metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation
MH  - Pregnancy
MH  - Receptors, Tumor Necrosis Factor/*genetics
MH  - Swine
MH  - TNF Receptor-Associated Factor 2/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2013/09/24 06:00
MHDA- 2014/07/09 06:00
CRDT- 2013/09/24 06:00
PHST- 2013/08/19 00:00 [accepted]
PHST- 2013/09/24 06:00 [entrez]
PHST- 2013/09/24 06:00 [pubmed]
PHST- 2014/07/09 06:00 [medline]
AID - 10.1007/s11259-013-9575-9 [doi]
PST - ppublish
SO  - Vet Res Commun. 2014 Mar;38(1):1-10. doi: 10.1007/s11259-013-9575-9. Epub 2013 
      Sep 22.