PMID- 24059294
OWN - NLM
STAT- MEDLINE
DCOM- 20140824
LR  - 20221207
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 36
IP  - 1
DP  - 2014 Feb
TI  - Monocyte chemoattractant protein-1 -2518G/A gene polymorphism and the risk of 
      nephropathy in type 2 diabetes mellitus among Asians: a meta-analysis.
PG  - 139-44
LID - 10.3109/0886022X.2013.832690 [doi]
AB  - The association between monocyte chemoattractant protein-1 (MCP-1) -2518G/A gene 
      polymorphism and the risk of nephropathy in type 2 diabetes mellitus (T2DM) 
      remains controversial. A meta-analysis was conducted to assess the association of 
      MCP-1 -2518G/A gene polymorphism with the risk of nephropathy in T2DM. Eight 
      studies were included in our meta-analysis by searching electronic databases 
      according to predefined criteria. No significant association between G allele, GG 
      genotype, or AA genotype and the onset of nephropathy in T2DM was observed among 
      Asians. GA genotype was significantly associated with nephropathy risk in T2DM 
      among Asians (p = 0.024). MCP-1 -2518G/A gene polymorphism was not associated 
      with nephropathy risk in T2DM among Chinese, Koreans, and Turks. For Indians, G 
      allele and AA genotype were not associated with nephropathy risk in T2DM, GG 
      genotype was associated with a lower risk of nephropathy in T2DM (p = 0.017), GA 
      genotype was associated with the susceptibility of nephropathy in T2DM 
      (p = 0.029). In conclusions, GA genotype might be a risk factor for the onset of 
      nephropathy in T2DM among Asians, particularly Indians; GG genotype seems to be a 
      protective factor against the susceptibility of nephropathy in T2DM among 
      Indians.
FAU - Mao, Song
AU  - Mao S
AD  - Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing 
      Medical University , Nanjing , China.
FAU - Huang, Songming
AU  - Huang S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20130924
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Nephropathies/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Genetic
EDAT- 2013/09/26 06:00
MHDA- 2014/08/26 06:00
CRDT- 2013/09/25 06:00
PHST- 2013/09/25 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/08/26 06:00 [medline]
AID - 10.3109/0886022X.2013.832690 [doi]
PST - ppublish
SO  - Ren Fail. 2014 Feb;36(1):139-44. doi: 10.3109/0886022X.2013.832690. Epub 2013 Sep 
      24.