PMID- 24059313
OWN - NLM
STAT- MEDLINE
DCOM- 20141205
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 13
IP  - 2
DP  - 2014 Mar
TI  - Role of gut microbiota in obesity, type 2 diabetes and Alzheimer's disease.
PG  - 305-11
AB  - In recent years, there is a growing interest in research to investigate the 
      importance of gut microbiome in health and diseases. This opens a new area of 
      research for the role of microbial flora of the human gut in inflammation, energy 
      homeostasis, pathogenesis of obesity and other associated disorders. Recent 
      studies propose association of the gut microbiome with development of obesity and 
      metabolic syndromes, such as type 2 diabetes mellitus (T2DM). The T2DM is a 
      metabolic disease that is mainly caused by obesity-linked insulin resistance. The 
      vascular effects of obesity appears to play a role in the development of 
      Alzheimer's disease (AD) that is one of the rapidly growing diseases of a late 
      stage of life all over the world. Studies from both humans and mice models have 
      been demonstrated the engagement of gut microbial flora in the pathogenesis of 
      obesity and host metabolism. The aim of this review is to discuss the current 
      findings that may explain the cascade of gut microbial flora participation in the 
      development of obesity, T2DM and further initiation of AD. In addition, the 
      available data regarding the mechanisms that have been proposed to elucidate the 
      role of gut microbiota in weight gain and possible cause of T2DM and AD have been 
      examined.
FAU - Naseer, Muhammad I
AU  - Naseer MI
FAU - Bibi, Fehmida
AU  - Bibi F
FAU - Alqahtani, Mohammed H
AU  - Alqahtani MH
FAU - Chaudhary, Adeel G
AU  - Chaudhary AG
FAU - Azhar, Esam I
AU  - Azhar EI
FAU - Kamal, Mohammad A
AU  - Kamal MA
FAU - Yasir, Muhammad
AU  - Yasir M
AD  - King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, 
      Saudi Arabia. yasirphr@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
SB  - IM
MH  - Alzheimer Disease/*microbiology/physiopathology
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*microbiology/physiopathology
MH  - Gastrointestinal Tract/*microbiology
MH  - Humans
MH  - *Microbiota
MH  - Obesity/*microbiology/physiopathology
EDAT- 2013/09/26 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/09/25 06:00
PHST- 2013/01/09 00:00 [received]
PHST- 2013/03/09 00:00 [revised]
PHST- 2013/03/17 00:00 [accepted]
PHST- 2013/09/25 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - CNSNDDT-EPUB-56152 [pii]
AID - 10.2174/18715273113126660147 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2014 Mar;13(2):305-11. doi: 
      10.2174/18715273113126660147.