PMID- 2406002
OWN - NLM
STAT- MEDLINE
DCOM- 19900319
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 65
IP  - 3 Suppl
DP  - 1990 Feb 1
TI  - Bone marrow transplantation in hematologic malignancies. Current status.
PG  - 786-91
AB  - Bone marrow transplantation (BMT) after supralethal cytoreductive therapy in the 
      acute leukemias, chronic myelogenous leukemia (CML), and the lymphomas may be 
      curative in 50% to 60% of patients. The donor may be a human leukocyte antigen 
      (HLA) matched family member (allogeneic), an identical twin (syngeneic), or the 
      patient (autologous). In general, the outcome is best in younger patients and 
      those transplanted early in their disease (i.e., in the first remission for acute 
      leukemia and in the chronic phase of the disease in CML). Solutions to the major 
      problems of allogeneic BMT, such as graft-versus-host disease and viral 
      infections, are being actively pursued. Syngeneic and autologous BMT avoids some 
      of the above problems, but relapses appear to be greater. Despite this problem, a 
      significant number of cures have been accomplished. Newer methods of purging 
      autologous marrow and newer preparative regimens promise to reduce the problem of 
      relapses.
FAU - Santos, G W
AU  - Santos GW
AD  - Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 
      21205.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - *Bone Marrow Transplantation
MH  - Family
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia/*surgery
MH  - Leukemia, Myeloid, Acute/*surgery
MH  - Lymphoma/*surgery
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/surgery
MH  - Prognosis
MH  - Transplantation, Autologous
MH  - Transplantation, Homologous/adverse effects
MH  - Transplantation, Isogeneic
RF  - 49
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
AID - 10.1002/1097-0142(19900201)65:3+<786::aid-cncr2820651326>3.0.co;2-h [doi]
PST - ppublish
SO  - Cancer. 1990 Feb 1;65(3 Suppl):786-91. doi: 
      10.1002/1097-0142(19900201)65:3+<786::aid-cncr2820651326>3.0.co;2-h.