PMID- 24060156
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20210405
IS  - 1029-2470 (Electronic)
IS  - 1029-2470 (Linking)
VI  - 48
IP  - 2
DP  - 2014 Feb
TI  - Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled 
      nitric oxide in healthy Japanese workers.
PG  - 137-45
LID - 10.3109/10715762.2013.842979 [doi]
AB  - The associations of serum arginase I with serum L-arginine, serum 
      3-nitrotyrosine, and fractional exhaled nitric oxide (FENO) were evaluated 
      cross-sectionally in healthy Japanese workers. The serum median (minimum-maximum) 
      levels of arginase I, 3-nitrotyrosine, and FENO in healthy people (n = 130) were 
      14.6 (0.94-108.1) ng/mL, 81.0 (0.27-298.6) pmol/mg protein, and 14.0 (5.0-110.0) 
      parts per billion, respectively. Significant correlations of arginase I with 
      FENO, L-arginine, 3-nitrotyrosine, and percent predicted forced expiratory volume 
      in 1 s (FEV1 (% predicted)) were observed, and correlations of FENO with 
      immunoglobulin E (IgE), NOx, arginase I, and sex and allergy were also observed. 
      By multiple regression analysis, arginase I showed positive associations with 
      FENO and 3-nitrotyrosine, and a negative association with L-arginine; and FENO 
      showed positive associations with IgE and NO2(-) + NO3(-) (NOx), and a negative 
      association with L-arginine, as well as an association with sex. Moreover, 
      logistic regression analysis showed linear inverse associations of arginase I and 
      3-nitrotyrosine with L-arginine, and showed linear positive associations of FENO 
      with IgE and NOx. It was concluded that serum arginase I might regulate serum 
      L-arginine and 3-nitrotyrosine via L-arginine, and that IgE or NOx might regulate 
      FENO in a healthy Japanese population.
FAU - Ogino, K
AU  - Ogino K
AD  - Department of Public Health, Okayama University, Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences , Okayama , Japan.
FAU - Wang, D H
AU  - Wang DH
FAU - Kubo, M
AU  - Kubo M
FAU - Obase, Y
AU  - Obase Y
FAU - Setiawan, H
AU  - Setiawan H
FAU - Yan, F
AU  - Yan F
FAU - Takahashi, H
AU  - Takahashi H
FAU - Zhang, R
AU  - Zhang R
FAU - Tsukiyama, Y
AU  - Tsukiyama Y
FAU - Yoshida, J
AU  - Yoshida J
FAU - Zou, Y
AU  - Zou Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131007
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 3604-79-3 (3-nitrotyrosine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 42HK56048U (Tyrosine)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 3.5.3.1 (ARG1 protein, human)
RN  - EC 3.5.3.1 (Arginase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arginase/*blood
MH  - Arginine/*blood
MH  - Cross-Sectional Studies
MH  - Exhalation
MH  - Female
MH  - Forced Expiratory Volume
MH  - Healthy Volunteers
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*metabolism
MH  - Tyrosine/*analogs & derivatives/blood
MH  - Young Adult
EDAT- 2013/09/26 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/09/25 06:00
PHST- 2013/09/25 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - 10.3109/10715762.2013.842979 [doi]
PST - ppublish
SO  - Free Radic Res. 2014 Feb;48(2):137-45. doi: 10.3109/10715762.2013.842979. Epub 
      2013 Oct 7.