PMID- 24060477
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20131202
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 18
IP  - 23-24
DP  - 2013 Dec
TI  - GPR119 agonists: a promising approach for T2DM treatment? A SWOT analysis of 
      GPR119.
PG  - 1309-15
LID - S1359-6446(13)00317-6 [pii]
LID - 10.1016/j.drudis.2013.09.011 [doi]
AB  - Ever since its advent as a promising therapeutic target for type 2 diabetes 
      mellitus (T2DM), G-protein-coupled receptor 119 (GPR119) has received much 
      interest from the pharmaceutical industry. This interest peaked in June 2010, 
      when Sanofi-Aventis agreed to pay Metabolex (Cymabay Therapeutics) US$375 million 
      for MBX-2982, which was a representative orally active GPR119 agonist. However, 
      Sanofi-Aventis opted to terminate the deal in May 2011 and another leading GPR119 
      agonist, GSK1292263, had a loss of efficacy during its clinical trial. In this 
      review, I discuss the pros and cons of GPR119 through a strengths, weaknesses, 
      opportunities, and threats (SWOT) analysis and propose development strategies for 
      the eventual success of a GPR119 agonist development program.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Kang, Sang-Uk
AU  - Kang SU
AD  - Kosin University, Department of Life Sciences, 149-1, Dongsam-dong, Yeongdogu, 
      Busan, South Korea. Electronic address: sanguk@kosin.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130920
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (GPR119 protein, human)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Receptors, G-Protein-Coupled)
SB  - IM
MH  - Animals
MH  - Clinical Trials as Topic
MH  - Diabetes Mellitus, Type 2/*drug therapy/physiopathology
MH  - Drug Design
MH  - Drug Industry/economics/methods
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - Receptors, G-Protein-Coupled/*agonists/metabolism
EDAT- 2013/09/26 06:00
MHDA- 2015/04/07 06:00
CRDT- 2013/09/25 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2013/08/20 00:00 [revised]
PHST- 2013/09/13 00:00 [accepted]
PHST- 2013/09/25 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - S1359-6446(13)00317-6 [pii]
AID - 10.1016/j.drudis.2013.09.011 [doi]
PST - ppublish
SO  - Drug Discov Today. 2013 Dec;18(23-24):1309-15. doi: 10.1016/j.drudis.2013.09.011. 
      Epub 2013 Sep 20.