PMID- 2406145 OWN - NLM STAT- MEDLINE DCOM- 19900321 LR - 20190813 IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 149 IP - 4 DP - 1990 Jan TI - Immunological features of diffuse connective tissue diseases. PG - 224-31 AB - Diffuse connective tissue diseases (DCTD) represent an heterogeneous group of disorders characterized by systemic inflammatory reactions that are currently classified on clinical grounds. Their aetiopathogenesis is largely unknown and appears to be very complex, associating exogenous factors with an immunogenetic predisposition. In the last decade, studies on human leukocyte antigen (HLA)-disease associations and antinuclear antibodies have provided some useful clues for the diagnosis and clinical management of DCTD. FAU - Burgio, G R AU - Burgio GR AD - Clinica Pediatrica, Universita di Pavia, Policlinico S. Matteo, Italy. FAU - Martini, A AU - Martini A LA - eng PT - Journal Article PT - Review PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Antibodies, Antinuclear) RN - 0 (HLA Antigens) SB - IM MH - Animals MH - Antibodies, Antinuclear/immunology MH - Connective Tissue Diseases/*immunology MH - Disease Models, Animal MH - HLA Antigens/immunology MH - Humans RF - 59 EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] AID - 10.1007/BF02106277 [doi] PST - ppublish SO - Eur J Pediatr. 1990 Jan;149(4):224-31. doi: 10.1007/BF02106277.