PMID- 24063204
OWN - NLM
STAT- MEDLINE
DCOM- 20150411
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 33
IP  - 7
DP  - 2013 Jul
TI  - [Effect of tongguan capsule on the number of endothelial progenitor cells in the 
      peripheral blood of patients with coronary artery disease after PCI].
PG  - 873-7
AB  - OBJECTIVE: To observe the effect of Tongguan Capsule (TC) on the number of 
      endothelial progenitor cells (EPCs) in the peripheral blood of patients with 
      coronary artery disease (CAD) after percutaneous coronary intervention (PCI). 
      METHODS: Recruited were 60 CAD patients undergoing PCI who were admitted and 
      treated at ICU and the Heart Center of Guangdong Provincial Hospital of 
      Traditional Chinese Medicine from March to October 2010. They were assigned to 
      the treatment group (treated by TC) and the control group (treated by placebos) 
      according to the random digit table, 30 cases in each group. They took TC or 
      placebos from the day of PCI, three pills each time, three times a day, for three 
      consecutive months. The numbers of peripheral blood CD34 and vascular endothelial 
      growth factor receptor-2 (VEGFR2) positive cells were detected before PCI and 3 
      months after PCI respectively. The echocardiography was performed before PCI and 
      3 months after PCI respectively to determinate the left ventricular end diastolic 
      volume (LVEDV), left ventricular end systolic volume (LVESV), stroke volume (SV), 
      cardiac output (CO), and left ventricular ejection fraction (LVEF). The wall 
      motion score index (WMSI) was assessed in the two groups. RESULTS: There was no 
      statistical difference in the number of EPCs, LVEF,WMSI, or SV in the two groups 
      before PCI (P > 0.05). The number of EPCs increased in both the two groups after 
      1 month of PCI (P < 0.05). It was obviously higher in the treatment group than in 
      the control group (P < 0.05). The LVEF both increased in the two groups 3 months 
      after PCI (P < 0.05, P < 0.01). The WMSI decreased and SV increased in the 
      treatment group (P < 0.05). The improvement of LVEF and WMSI was better in the 
      treatment group than in the control group (P < 0.05). CONCLUSION: TC could 
      up-regulate the number of EPCs in the peripheral blood of CAD patients after PCI, 
      and improve their cardiac functions.
FAU - Chen, Peng
AU  - Chen P
AD  - ICU of Second Affiliated Hospital, Guangzhou University of Traditional Chinese 
      Medicine, Guangzhou 510120, China.
FAU - Zhu, Chu-Lin
AU  - Zhu CL
FAU - Zhang, Min-Zhou
AU  - Zhang MZ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (tongguan)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Cell Count
MH  - Coronary Artery Disease/*drug therapy/therapy
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Endothelial Progenitor Cells/cytology/*drug effects
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Phytotherapy
EDAT- 2013/09/26 06:00
MHDA- 2015/04/12 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2015/04/12 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jul;33(7):873-7.