PMID- 24063213
OWN - NLM
STAT- MEDLINE
DCOM- 20150411
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 33
IP  - 7
DP  - 2013 Jul
TI  - [Expressions of TNF-alpha, IL-6, CRP, and MCP-1 in phlegm-damp constitution 
      population detected by multiplexed Luminex assay].
PG  - 920-3
AB  - OBJECTIVE: To study the expression changes of tumor necrosis factor-alpha 
      (TNF-(alpha), interleukin-6 (IL-6), C-reactive protein (CRP), monocyte 
      chemotactic protein 1 (MCP-1), and their correlation with obesity in 20 -50 years 
      old population of phlegm-damp constitution (PDC) and of normal constitution (NC) 
      using Luminex technique. METHODS: Totally 101 population were recruited from 
      Health Examination Center of Puren Hospital from April to December 2011. Based on 
      body mass index (BMI), the subjects were assigned to four groups, i.e., the 
      obesity of PDC group (Group OBT, BMI > or = 24 kg/m2, 30 cases), the non-obesity 
      of PDC group (Group NOBT, BMI < 24 kg/m2, 25 cases), the obesity of non-PDC group 
      (Group OBNT, BMI > or = 24 kg/m2, 28 cases), the NC group (Group P, BMI < 24 
      kg/m2, 18 cases). The BMI and body fat percent (FAT%) were compared among the 4 
      groups. Serum levels of TNF-alpha, IL-6, CRP, and MCP-1 were measured with 
      Luminex technique. RESULTS: BMI was significantly higher in Group OBT and Group 
      OBNT than in Group NOBT and Group P (all P < 0.05). The FAT% was significantly 
      higher in Group OBT and Group OBNT than in Group P (P < 0.01). The serum 
      TNF-alpha level in Group OBT was higher than in Group P (P < 0.01). The serum CRP 
      and MCP-1 levels were significantly higher in Group OBT, NOBT, and OBNT than in 
      Group P (P < 0.05, P < 0.01). The score for PDC was positively correlated with 
      TNF-alpha, IL-6, and MCP-1 levels (P < 0.05). CONCLUSIONS: Abnormal higher levels 
      of inflammatory factors exist in 20 -50 years old population of PDC. Chronic 
      inflammation exists in population of PDC and obesity people.
FAU - Zheng, Lu-Yu
AU  - Zheng LY
AD  - Center for Traditional Chinese Medicine Constitution Research, School of Basic 
      Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
FAU - Yang, Ling-Ling
AU  - Yang LL
FAU - Li, Ling-Ru
AU  - Li LR
FAU - Jing, Hui-Ru
AU  - Jing HR
FAU - Wang, Ji
AU  - Wang J
FAU - Wang, Qian-Fei
AU  - Wang QF
FAU - Wang, Qi
AU  - Wang Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/blood
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - *Microchip Analytical Procedures
MH  - Middle Aged
MH  - Obesity/*blood/*diagnosis
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2013/09/26 06:00
MHDA- 2015/04/12 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2015/04/12 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jul;33(7):920-3.