PMID- 24063839
OWN - NLM
STAT- MEDLINE
DCOM- 20140128
LR  - 20220311
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 112
IP  - 12
DP  - 2013 Dec 15
TI  - Outcome after ST elevation myocardial infarction in patients with cancer treated 
      with primary percutaneous coronary intervention.
PG  - 1867-72
LID - S0002-9149(13)01701-3 [pii]
LID - 10.1016/j.amjcard.2013.08.019 [doi]
AB  - The simultaneous occurrence of cancer and coronary heart disease is increasing in 
      the Western world. Nevertheless, the influence of cancer on ST elevation 
      myocardial infarction (STEMI) treated with primary percutaneous coronary 
      intervention (PCI) has not been investigated extensively. This multicenter 
      registry included patients with STEMI treated with primary PCI from 2006 to 2009. 
      Patients were stratified according to history of cancer, and primary focus lay on 
      all-cause and cardiac mortalities during 1-year follow-up. Adjusted effect sizes 
      were calculated using Cox proportional hazard models. In total, 208 patients had 
      a history of cancer (diagnosed </=6 months ago in 20.7%, 6 months to 3 years ago in 
      21.7%, and >3 years ago in 57.6%) and 3,215 patients had no history of cancer. 
      Chemotherapy had been administered previously to 23% of patients with cancer. 
      Patients with cancer were older, more frequently women, and more commonly known 
      with previous myocardial infarction or anemia. Reperfusion rates were similar 
      after PCI. Patients with cancer showed greater all-cause (17.4% vs 6.5% in other 
      patients) and cardiac mortalities at 1 year (10.7% vs 5.4% in other patients) 
      because of high early cardiac death (23.8%) in recently diagnosed patients with 
      cancer. After adjustment, a recent cancer diagnosis predicted cardiac mortality 
      at 7 days (hazard ratio 3.34, 95% confidence interval 1.57 to 7.08). The adverse 
      prognosis was partly explained by anemia and occurrence of cardiogenic shock, 
      whereas outcome was independent of cancer treatment. In conclusion, patients with 
      cancer showed greater mortality after STEMI. A cancer diagnosis in the 6 months 
      before primary PCI was strongly associated with early cardiac mortality.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Velders, Matthijs A
AU  - Velders MA
AD  - Department of Cardiology, Medical Center Leeuwarden, Leeuwarden, The Netherlands; 
      Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands. Electronic address: m.a.velders@lumc.nl.
FAU - Boden, Helen
AU  - Boden H
FAU - Hofma, Sjoerd H
AU  - Hofma SH
FAU - Osanto, Susanne
AU  - Osanto S
FAU - van der Hoeven, Bas L
AU  - van der Hoeven BL
FAU - Heestermans, Anton A C M
AU  - Heestermans AA
FAU - Cannegieter, Suzanne C
AU  - Cannegieter SC
FAU - Jukema, J Wouter
AU  - Jukema JW
FAU - Umans, Victor A W M
AU  - Umans VA
FAU - Schalij, Martin J
AU  - Schalij MJ
FAU - van Boven, Adrianus J
AU  - van Boven AJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130921
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Anemia/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*epidemiology/mortality/therapy
MH  - Neoplasms/*epidemiology
MH  - Percutaneous Coronary Intervention
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Registries
MH  - Shock, Cardiogenic/epidemiology
EDAT- 2013/09/26 06:00
MHDA- 2014/01/29 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/06/28 00:00 [received]
PHST- 2013/08/06 00:00 [revised]
PHST- 2013/08/06 00:00 [accepted]
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/01/29 06:00 [medline]
AID - S0002-9149(13)01701-3 [pii]
AID - 10.1016/j.amjcard.2013.08.019 [doi]
PST - ppublish
SO  - Am J Cardiol. 2013 Dec 15;112(12):1867-72. doi: 10.1016/j.amjcard.2013.08.019. 
      Epub 2013 Sep 21.