PMID- 24063842
OWN - NLM
STAT- MEDLINE
DCOM- 20140128
LR  - 20211021
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 112
IP  - 12
DP  - 2013 Dec 15
TI  - Comparison of predictors of heart failure-related hospitalization or death in 
      patients with versus without preserved left ventricular ejection fraction.
PG  - 1907-12
LID - S0002-9149(13)01696-2 [pii]
LID - 10.1016/j.amjcard.2013.08.014 [doi]
AB  - Heart failure with preserved ejection fraction (HFpEF) is recognized as a major 
      cause of cardiovascular morbidity and mortality. An ability to identify patients 
      with HFpEF who are at increased risk for adverse outcomes can facilitate their 
      more careful management. We studied the patients having heart failure (HF) using 
      data from the Heart Failure Adherence and Retention Trial (HART). HART enrolled 
      902 patients in the New York Heart Association (NYHA) class II or III who had 
      been recently hospitalized for HF to study the impact of self-management 
      counseling on the primary outcome of death or HF hospitalization. In HART, 208 
      patients had HFpEF and 692 had HF with reduced ejection fraction (HFrEF) and were 
      followed for a median of 1,080 days. Two final multivariate models were 
      developed. In patients having HFpEF, predictors of primary outcome were male 
      gender (odds ratio [OR] 3.45, p = 0.004), NYHA class III (OR 3.05, p = 0.008), 
      distance covered on a 6-minute walk test (6-MWT) of <620 feet (OR 2.81, p = 
      0.013), and <80% adherence to prescribed medications (OR 2.61, p = 0.018). In 
      patients having HFrEF, the predictors were being on diuretics (OR 3.06, p = 
      0.001), having >/=3 co-morbidities (OR 2.11, p = 0.0001), distance covered on a 
      6-MWT of <620 feet (OR 1.94, p = 0.001), NYHA class III (OR 1.90, p = 0.001), and 
      age >65 years (OR 1.63, p = 0.01). In conclusion, indicators of functional status 
      (6-MWT and NYHA class) were common to both patients with HFpEF and those with 
      HFrEF, whereas gender and adherence to prescribed therapy were unique to patients 
      having HFpEF in predicting death or HF hospitalization.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Mangla, Ashvarya
AU  - Mangla A
AD  - Department of Internal Medicine, Weiss Memorial Hospital, Chicago, Illinois; 
      Department of Preventive Medicine, Rush University Medical Center, Chicago, 
      Illinois. Electronic address: ashmangla@gmail.com.
FAU - Kane, John
AU  - Kane J
FAU - Beaty, Elijah
AU  - Beaty E
FAU - Richardson, DeJuran
AU  - Richardson D
FAU - Powell, Lynda H
AU  - Powell LH
FAU - Calvin, James E Jr
AU  - Calvin JE Jr
LA  - eng
GR  - R01 HL065547/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130921
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Diabetic Angiopathies/epidemiology
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*mortality/*physiopathology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Medication Adherence
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - *Stroke Volume
PMC - PMC3880823
MID - NIHMS526653
EDAT- 2013/09/26 06:00
MHDA- 2014/01/29 06:00
PMCR- 2014/12/15
CRDT- 2013/09/26 06:00
PHST- 2013/06/01 00:00 [received]
PHST- 2013/08/14 00:00 [revised]
PHST- 2013/08/14 00:00 [accepted]
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/01/29 06:00 [medline]
PHST- 2014/12/15 00:00 [pmc-release]
AID - S0002-9149(13)01696-2 [pii]
AID - 10.1016/j.amjcard.2013.08.014 [doi]
PST - ppublish
SO  - Am J Cardiol. 2013 Dec 15;112(12):1907-12. doi: 10.1016/j.amjcard.2013.08.014. 
      Epub 2013 Sep 21.