PMID- 24065151
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20140331
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 51
IP  - 2
DP  - 2014 Apr
TI  - Increasing burden, younger age at onset and worst metabolic control in migrant 
      than in Italian children with type 1 diabetes: an emerging problem in pediatric 
      clinics.
PG  - 263-7
LID - 10.1007/s00592-013-0514-6 [doi]
AB  - To assess burden and clinical features of type 1 diabetes in migrant with respect 
      to Italian children. Prevalent children with type 1 diabetes were identified 
      through a multicenter study, including 46 pediatric outpatients diabetic clinics. 
      A nested case-control study was also performed, comparing features at diabetes 
      onset and after 1 year of insulin treatment in 84 migrants and 75 Italian 
      children with onset in 2011, matched for age and sex. Out of 7,812 children cared 
      for by pediatric diabetologists, 761 (10%) were migrant and 548 of them were born 
      in Italy. Age at diagnosis was lower in migrants born in Italy (5.1 years, 
      interquartile range (IQR) 2.2-7.7) than in those born in their original countries 
      (7.8 years, IQR 5.3-10.3) and in Italians (9.8 years, IQR 5.9-13.0, p < 0.001). 
      At diabetes onset, migrants had lower frequencies of positivities of markers of 
      beta-cell autoimmunity (96 vs. 99.5%, p < 0.01), higher values of weight loss (11 
      vs. 7%, p < 0.01), HbA1c (70 vs. 58 mmol/mol, p < 0.001), and insulin requirement 
      (0.70 +/- 0.03 vs. 0.63 +/- 0.10 UI/kg/die, p = 0.05) and lower levels of 25-OH 
      vitamin D3 (15.0 +/- 2.8 vs. 20.8 +/- 1.3, p = 0.03). Moreover, they experienced 
      higher frequencies of hospitalizations during the first year of disease (19.2 vs. 
      2.7%, p < 0.001). Burden of type 1 diabetes in migrant children is increasing in 
      Italy, with younger age at onset and different clinical features than in Italian 
      children. Higher hospitalization rates and poorer glycemic control over the first 
      year underline that approach to diabetes care in migrants needs to be improved.
FAU - Cadario, Francesco
AU  - Cadario F
AD  - Division of Pediatrics, Department of Health Sciences, Universita del "Piemonte 
      Orientale Amedeo Avogadro", Novara, Italy.
FAU - Cerutti, Franco
AU  - Cerutti F
FAU - Savastio, Silvia
AU  - Savastio S
FAU - Rabbone, Ivana
AU  - Rabbone I
FAU - Tumini, Stefano
AU  - Tumini S
FAU - Bruno, Graziella
AU  - Bruno G
CN  - Italian Society of Pediatric Endocrinology and Diabetology Study Group (SIEDP)
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130925
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/drug therapy/epidemiology/genetics/*metabolism
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Insulin/*therapeutic use
MH  - Italy/epidemiology
MH  - Male
MH  - Prevalence
MH  - Statistics, Nonparametric
MH  - Transients and Migrants
FIR - Lera, R
IR  - Lera R
FIR - Cherubini, V
IR  - Cherubini V
FIR - Bechaz, M
IR  - Bechaz M
FIR - Zucchini, S
IR  - Zucchini S
FIR - Prandi, E
IR  - Prandi E
FIR - Zattoni, V
IR  - Zattoni V
FIR - Coccioli, S
IR  - Coccioli S
FIR - Frongia, A P
IR  - Frongia A
FIR - La Loggia, A
IR  - La Loggia A
FIR - Lo Presti, D
IR  - Lo Presti D
FIR - Citrini, F
IR  - Citrini F
FIR - Suprani, T
IR  - Suprani T
FIR - Dedonno, V
IR  - Dedonno V
FIR - Vergerio, A
IR  - Vergerio A
FIR - Banin, P
IR  - Banin P
FIR - Toni, S
IR  - Toni S
FIR - Piccini, B
IR  - Piccini B
FIR - Barni, F
IR  - Barni F
FIR - Pescamona, M
IR  - Pescamona M
FIR - Cardinale, G
IR  - Cardinale G
FIR - Lombardo, F
IR  - Lombardo F
FIR - Bonfanti, R
IR  - Bonfanti R
FIR - Scaramuzza, A
IR  - Scaramuzza A
FIR - Iughetti, L
IR  - Iughetti L
FIR - Franzese, A
IR  - Franzese A
FIR - Iafusco, D
IR  - Iafusco D
FIR - Guercio Nuzio, S
IR  - Guercio Nuzio S
FIR - Abiuso, C
IR  - Abiuso C
FIR - Monciotti, C
IR  - Monciotti C
FIR - Cardella, F
IR  - Cardella F
FIR - Vanelli, M
IR  - Vanelli M
FIR - Chiari, G
IR  - Chiari G
FIR - Calcaterra, V
IR  - Calcaterra V
FIR - De Giorgi, G
IR  - De Giorgi G
FIR - Zanette, G
IR  - Zanette G
FIR - Marsciani, A
IR  - Marsciani A
FIR - Patera, P
IR  - Patera P
FIR - Manca Bitti, M L
IR  - Manca Bitti M
FIR - Delvecchio, M
IR  - Delvecchio M
FIR - Trada, M
IR  - Trada M
FIR - Aimar, A
IR  - Aimar A
FIR - Gaiero, A
IR  - Gaiero A
FIR - Tinti, D
IR  - Tinti D
FIR - Fontana, F
IR  - Fontana F
FIR - Guerraggio, L
IR  - Guerraggio L
FIR - Cauvin, V
IR  - Cauvin V
FIR - Gargantini, L
IR  - Gargantini L
FIR - Salvatoni, A
IR  - Salvatoni A
FIR - Trivellin, V
IR  - Trivellin V
FIR - Maffeis, C
IR  - Maffeis C
FIR - Marigliano, M
IR  - Marigliano M
FIR - Arnaldi, C
IR  - Arnaldi C
EDAT- 2013/09/26 06:00
MHDA- 2016/05/20 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2013/09/11 00:00 [accepted]
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - 10.1007/s00592-013-0514-6 [doi]
PST - ppublish
SO  - Acta Diabetol. 2014 Apr;51(2):263-7. doi: 10.1007/s00592-013-0514-6. Epub 2013 
      Sep 25.