PMID- 24065684
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20130925
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 12
IP  - 3
DP  - 2013 Sep 10
TI  - Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 
      diabetes mellitus in a Han Chinese population.
PG  - 3455-64
LID - 10.4238/2013.September.10.2 [doi]
AB  - Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is 
      expressed in different tissues and cells, including the pancreas and lymphocytes, 
      and it can selectively induce apoptosis in tumor cells but not in most normal 
      cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in 
      type 2 diabetes mellitus (T2DM). We recently discovered the association of 
      nonalcoholic fatty liver disease, a risk factor for T2DM, with a single 
      nucleotide polymorphism (SNP) in the TRAIL (TNFSF10) gene at site 1595C/T 
      (rs1131580), indicating the possible association of T2DM with this TRAIL 
      polymorphism. The aim of this study was to investigate the relationship of the 
      TRAIL SNP at site 1595C/T (rs1131580) with T2DM susceptibility and the 
      biometabolic parameters of T2DM in a Han Chinese population. The polymerase chain 
      reaction-restriction fragment length polymorphism method was used to genotype SNP 
      rs1131580 in 292 patients with T2DM and 266 healthy controls. We found that the 
      frequency of the CC genotype and that of the C allele of rs1131580 were 
      significantly higher in T2DM patients than in the control group. Additionally, 
      the triglyceride and serum creatinine levels of T2DM patients with the CC 
      genotype were significantly higher than those of patients with the TT genotype. 
      Thus, the CC genotype of the TRAIL SNP at 1595C/T (rs1131580) confers increased 
      susceptible to T2DM in a Han Chinese population from Shandong Province. These 
      data suggest that the CC genotype at this SNP is related to diabetic severity and 
      it might be a candidate for the prognostic assessment of T2DM.
FAU - Yu, M Y
AU  - Yu MY
AD  - Key Laboratory for Experimental Teratology of Ministry of Education, Shandong 
      Provincial Key Laboratory of Infection & Immunology, Institute of Immunology, 
      Shandong University School of Medicine, Shandong, China.
FAU - Zhao, P Q
AU  - Zhao PQ
FAU - Yan, X H
AU  - Yan XH
FAU - Liu, B
AU  - Liu B
FAU - Zhang, Q Q
AU  - Zhang QQ
FAU - Wang, R
AU  - Wang R
FAU - Ma, C H
AU  - Ma CH
FAU - Liang, X H
AU  - Liang XH
FAU - Zhu, F L
AU  - Zhu FL
FAU - Gao, L F
AU  - Gao LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130910
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNFSF10 protein, human)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - TNF-Related Apoptosis-Inducing Ligand/*genetics
EDAT- 2013/09/26 06:00
MHDA- 2014/04/09 06:00
CRDT- 2013/09/26 06:00
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - gmr2465 [pii]
AID - 10.4238/2013.September.10.2 [doi]
PST - epublish
SO  - Genet Mol Res. 2013 Sep 10;12(3):3455-64. doi: 10.4238/2013.September.10.2.