PMID- 24066191
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20211021
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2013
DP  - 2013
TI  - Status of systemic oxidative stress during therapeutic hypothermia in patients 
      with post-cardiac arrest syndrome.
PG  - 562429
LID - 10.1155/2013/562429 [doi]
LID - 562429
AB  - Therapeutic hypothermia (TH) is thought to be due to the downregulation of free 
      radical production, although the details of this process remain unclear. Here, we 
      investigate changes in oxidative stress and endogenous biological antioxidant 
      potential during TH in patients with post-cardiac arrest syndrome (PCAS). 
      Nineteen PCAS patients were enrolled in the study. Brain temperature was 
      decreased to the target temperature of 33 degrees C, and it was maintained for 24 h. 
      Patients were rewarmed slowly (0.1 degrees C/h, <1 degrees C/day). The generation of reactive 
      oxygen metabolites (ROMs) was evaluated in plasma samples by d-ROM test. Plasma 
      antioxidant capacity was measured by the biological antioxidant potential (BAP) 
      test. Levels of d-ROMs and BAP levels during the hypothermic stage (33 degrees C) were 
      suppressed significantly compared with pre-TH induction levels (P < 0.05), while 
      both d-ROM and BAP levels increased with rewarming (33-36 degrees C) and were correlated 
      with brain temperature. Clinical monitoring of oxidative stress and antioxidant 
      potential is useful for evaluating the redox state of patients undergoing TH 
      after PCAS. Additional therapy to support the antioxidant potential in the 
      rewarming stage following TH may reduce some of the observed side effects 
      associated with the use of TH.
FAU - Dohi, Kenji
AU  - Dohi K
AD  - Department of Emergency and Critical Care Medicine, Showa University Fujigaoka 
      Hospital, Aoba-ku, Yokohama, Kanagawa 227-8501, Japan. kdoppy@yahoo.co.jp
FAU - Miyamoto, Kazuyuki
AU  - Miyamoto K
FAU - Fukuda, Kenichiro
AU  - Fukuda K
FAU - Nakamura, Shunsuke
AU  - Nakamura S
FAU - Hayashi, Munetaka
AU  - Hayashi M
FAU - Ohtaki, Hirokazu
AU  - Ohtaki H
FAU - Shioda, Seiji
AU  - Shioda S
FAU - Aruga, Tohru
AU  - Aruga T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130826
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Heart Arrest/*metabolism/*therapy
MH  - Humans
MH  - Hypothermia, Induced/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
MH  - Reactive Oxygen Species/metabolism
PMC - PMC3770059
EDAT- 2013/09/26 06:00
MHDA- 2014/02/20 06:00
PMCR- 2013/08/26
CRDT- 2013/09/26 06:00
PHST- 2013/03/29 00:00 [received]
PHST- 2013/06/18 00:00 [revised]
PHST- 2013/07/02 00:00 [accepted]
PHST- 2013/09/26 06:00 [entrez]
PHST- 2013/09/26 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
PHST- 2013/08/26 00:00 [pmc-release]
AID - 10.1155/2013/562429 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2013;2013:562429. doi: 10.1155/2013/562429. Epub 2013 Aug 
      26.