PMID- 24067327
OWN - NLM
STAT- MEDLINE
DCOM- 20141128
LR  - 20161020
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Jan
TI  - Increase in brain-derived neurotrophic factor expression in early crack cocaine 
      withdrawal.
PG  - 33-40
LID - 10.1017/S146114571300103X [doi]
AB  - Recent reports suggest that brain-derived neurotrophic factor (BDNF) could be a 
      biomarker for relapse, drug craving and withdrawal severity. In particular, 
      elevated BDNF levels among former cocaine users have been associated with higher 
      rates of relapse in 90 d. However, no data are available on BDNF levels at 
      baseline and during crack cocaine withdrawal. This study evaluated BDNF among 
      crack cocaine users during inpatient treatment, before and after withdrawal, vs. 
      healthy controls. Clinical correlates with changes in BDNF levels were also 
      assessed. Serum BDNF was evaluated in 49 male crack users on the first and last 
      days of hospitalization and in 97 healthy controls. Serum BDNF was assayed using 
      a sandwich ELISA kit. BDNF levels were significantly lower upon admission when 
      compared to controls, even after adjustment for age, length of inpatient 
      treatment, number of crack rocks used in the last 30 d, years of crack use and 
      interaction between the latter two variables. At discharge, BDNF levels between 
      patients and controls were similar. Number of crack rocks used in the last 30 d 
      and years of crack use were inversely correlated with the outcome. Our findings 
      show that BDNF levels increase during early crack cocaine withdrawal, at an 
      inverse correlation with number of crack rocks used in the last 30 d and years of 
      crack use.
FAU - von Diemen, Lisia
AU  - von Diemen L
AD  - Center for Drug and Alcohol Research, Hospital de Clinicas de Porto Alegre 
      (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, 
      Brazil.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Sordi, Anne Orgle
AU  - Sordi AO
FAU - de Magalhaes Narvaez, Joana Correa
AU  - de Magalhaes Narvaez JC
FAU - Guimaraes, Luciano Santos Pinto
AU  - Guimaraes LS
FAU - Kessler, Felix Henrique Paim
AU  - Kessler FH
FAU - Pfaffenseller, Bianca
AU  - Pfaffenseller B
FAU - de Aguiar, Bianca Wollenhaupt
AU  - de Aguiar BW
FAU - de Moura Gubert, Carolina
AU  - de Moura Gubert C
FAU - Pechansky, Flavio
AU  - Pechansky F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130926
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Crack Cocaine)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cocaine-Related Disorders/*blood
MH  - Crack Cocaine/*adverse effects
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Substance Withdrawal Syndrome/*blood
MH  - Young Adult
EDAT- 2013/09/27 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/09/27 06:00
PHST- 2013/09/27 06:00 [entrez]
PHST- 2013/09/27 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S146114571300103X [pii]
AID - 10.1017/S146114571300103X [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Jan;17(1):33-40. doi: 10.1017/S146114571300103X. 
      Epub 2013 Sep 26.