PMID- 24067471
OWN - NLM
STAT- MEDLINE
DCOM- 20140328
LR  - 20221207
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 26
IP  - 3
DP  - 2013 Jul-Sep
TI  - Association of HLA-DQB1*0501 with scleroderma and its clinical features in 
      Chinese population.
PG  - 747-51
AB  - Specific human leukocyte antigen (HLA) DQB1 alleles confer strong susceptibility 
      to systemic sclerosis (SSc). However, the frequencies of specific DQB1 alleles 
      and their associations with SSc vary according to ethnicity and clinical features 
      of SSc. The aim of this study was to profile DQB1 alleles in a Chinese population 
      and to identify specific DQB1 alleles in association with SSc of Han Chinese. A 
      cohort containing 213 patients with SSc and 239 gender-matched and unrelated 
      controls was examined in the study. The HLA-DQB1 genotyping was performed with 
      sequence-based typing (SBT) method. Exact p-values were obtained (Fisher's test) 
      from 2x2 tables of allele counts or allele carriers and disease status. Seventeen 
      DQB1 alleles were found in the cohort. DQB1*03:03 was the most common allele in 
      this cohort. DQB1*05:01 was significantly increased in SSc, and was strongly 
      associated with anti-centromere autoantibodies (ACA). Compared with SSc in other 
      ethnic populations, SSc patients of Han Chinese are distinct in association with 
      DQB1*06:11, common in association with DQB1*05:01, but lack association with 
      DQB1*03:01. In addition, DQB1*06:01 appeared more common in ATA-positive Chinese 
      SSc, and marginally associated with pulmonary fibrosis, and an increased 
      frequency of DQB1*03:03 was observed in anti-U1RNP-positive Chinese SSc patients.
FAU - Zhou, X D
AU  - Zhou XD
AD  - Division of Rheumatology and Clinical Immunogenetics, University of Texas Medical 
      School, Houston, USA.
FAU - Yi, L
AU  - Yi L
FAU - Guo, X J
AU  - Guo XJ
FAU - Chen, E
AU  - Chen E
FAU - Zou, H J
AU  - Zou HJ
FAU - Jin, L
AU  - Jin L
FAU - Mayes, M D
AU  - Mayes MD
FAU - Assassi, S
AU  - Assassi S
FAU - Wang, J C
AU  - Wang JC
LA  - eng
GR  - P50 AR054144/AR/NIAMS NIH HHS/United States
GR  - R01 AR055258/AR/NIAMS NIH HHS/United States
GR  - U01 AI090909/AI/NIAID NIH HHS/United States
GR  - 1U01AI09090/AI/NIAID NIH HHS/United States
PT  - Letter
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (anticentromere antibody)
SB  - IM
MH  - Antibodies, Antinuclear/blood
MH  - Asian People/*genetics
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Phenotype
MH  - Pulmonary Fibrosis/blood/ethnology/genetics/immunology
MH  - Risk Factors
MH  - Scleroderma, Systemic/blood/ethnology/*genetics/immunology
PMC - PMC3887513
MID - NIHMS543413
COIS- DISCLOSURE: ALL AUTHORS REPORT NO CONFLICTS OF INTEREST RELEVANT TO THIS ARTICLE.
EDAT- 2013/09/27 06:00
MHDA- 2014/03/29 06:00
PMCR- 2014/07/01
CRDT- 2013/09/27 06:00
PHST- 2013/09/27 06:00 [entrez]
PHST- 2013/09/27 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 18 [pii]
AID - 10.1177/039463201302600318 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):747-51. doi: 
      10.1177/039463201302600318.