PMID- 24068035 OWN - NLM STAT- MEDLINE DCOM- 20140515 LR - 20211021 IS - 1367-4811 (Electronic) IS - 1367-4803 (Print) IS - 1367-4803 (Linking) VI - 29 IP - 24 DP - 2013 Dec 15 TI - BlastGraph: a comparative genomics tool based on BLAST and graph algorithms. PG - 3222-4 LID - 10.1093/bioinformatics/btt553 [doi] AB - BlastGraph is an interactive Java program for comparative genome analysis based on Basic Local Alignment Search Tool (BLAST), graph clustering and data visualization. The software generates clusters of sequences of multiple genomes from all-to-all BLAST results and visualizes the results in graph plots together with related information such as sequence features, gene conservation and similarity relationships. Pruning algorithms are used to reduce results to more meaningful subclusters. Subsequent analyses can then be conducted based on the predicted clusters, including gene content, genome phylogenetics and gene gain and loss. AVAILABILITY AND IMPLEMENTATION: https://github.com/bigwiv/BlastGraph. FAU - Ye, Yanbo AU - Ye Y AD - Key Laboratory of Agricultural and Environmental Microbiology, Wuhan Institute of Virology, Wuhan, Hubei, China, 430071, Graduate School of Chinese Academy of Sciences, Beijing, China and Exiqon A/S, Vedbaek, Denmark. FAU - Wei, Bo AU - Wei B FAU - Wen, Lei AU - Wen L FAU - Rayner, Simon AU - Rayner S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130924 PL - England TA - Bioinformatics JT - Bioinformatics (Oxford, England) JID - 9808944 SB - IM MH - *Algorithms MH - Cluster Analysis MH - Computational Biology/*methods MH - *Computer Graphics MH - Genomics/*methods MH - Phylogeny MH - Sequence Alignment MH - Software PMC - PMC5994941 EDAT- 2013/09/27 06:00 MHDA- 2014/05/16 06:00 PMCR- 2014/12/15 CRDT- 2013/09/27 06:00 PHST- 2013/09/27 06:00 [entrez] PHST- 2013/09/27 06:00 [pubmed] PHST- 2014/05/16 06:00 [medline] PHST- 2014/12/15 00:00 [pmc-release] AID - btt553 [pii] AID - 10.1093/bioinformatics/btt553 [doi] PST - ppublish SO - Bioinformatics. 2013 Dec 15;29(24):3222-4. doi: 10.1093/bioinformatics/btt553. Epub 2013 Sep 24.