PMID- 24068187
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 46
IP  - 9
DP  - 2013 Sep
TI  - Evidence for the involvement of peripheral beta-adrenoceptors in delayed liquid 
      gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats.
PG  - 735-8
LID - S0100-879X2013000900735 [pii]
LID - 10.1590/1414-431X20132975 [doi]
AB  - Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric 
      emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon 
      in a study in male Wistar rats (250-300 g) pretreated subcutaneously with 
      guanethidine (GUA), 100 mg.kg-1.day-1, or vehicle (V) for 2 days before 
      experimental treatments. Other groups of animals were pretreated intravenously 
      (iv) 15 min before treatment with V, prazosin (PRA; 1 mg/kg), yohimbine (YOH; 3 
      mg/kg), or propranolol (PRO; 4 mg/kg), or with intracerebroventricular (icv) 
      administration of 25 microg PRO or V. The groups were treated iv with saline or with 
      240 micromol/kg Dp, AA, or At. GE was determined 10 min later by measuring the 
      percentage of gastric retention (%GR) of saline labeled with phenol red 10 min 
      after gavage. %GR (mean +/- SE, n=8) indicated that GUA abolished the effect of Dp 
      (GUA vs V=31.7 +/- 1.6 vs 47.1 +/- 2.3%) and of At (33.2 +/- 2.3 vs 54.7 +/- 3.6%) on GE 
      and significantly reduced the effect of AA (48.1 +/- 3.2 vs 67.2 +/- 3.1%). PRA and 
      YOH did not modify the effect of the drugs. %GR (mean +/- SE, n=8) indicated that 
      iv, but not icv, PRO abolished the effect of Dp (PRO vs V=29.1 +/- 1.7 vs 46.9 +/- 
      2.7%) and At (30.5 +/- 1.7 vs 49 +/- 3.2%) and significantly reduced the effect of AA 
      (48.4 +/- 2.6 vs 59.5 +/- 3.1%). These data suggest activation of peripheral 
      beta-adrenoceptors in the delayed GE induced by phenylpyrazolone derivatives.
FAU - Vinagre, A M
AU  - Vinagre AM
AD  - Universidade Estadual de Campinas, Nucleo de Medicina e Cirurgia Experimental, 
      Faculdade de Ciencias Medicas, CampinasSP, Brasil.
FAU - Collares, E F
AU  - Collares EF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130927
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Adrenergic Antagonists)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Receptors, Adrenergic, beta)
RN  - 0M0B7474RA (Ampyrone)
RN  - 2Y49VWD90Q (Yohimbine)
RN  - 6429L0L52Y (Dipyrone)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - I6G9Y0J1OJ (Phenolsulfonphthalein)
RN  - T3CHA1B51H (Antipyrine)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Adrenergic Antagonists/*administration & dosage
MH  - Ampyrone/*administration & dosage
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage
MH  - Antipyrine/*administration & dosage
MH  - Dipyrone/*administration & dosage
MH  - Gastric Emptying/*drug effects
MH  - Infusions, Intraventricular
MH  - Male
MH  - Phenolsulfonphthalein
MH  - Prazosin/administration & dosage
MH  - Propranolol/administration & dosage
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, beta/*metabolism
MH  - Yohimbine/administration & dosage
PMC - PMC3854428
EDAT- 2013/09/27 06:00
MHDA- 2014/11/13 06:00
PMCR- 2013/09/27
CRDT- 2013/09/27 06:00
PHST- 2013/02/16 00:00 [received]
PHST- 2013/07/15 00:00 [accepted]
PHST- 2013/09/27 06:00 [entrez]
PHST- 2013/09/27 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
PHST- 2013/09/27 00:00 [pmc-release]
AID - S0100-879X2013000900735 [pii]
AID - 10.1590/1414-431X20132975 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2013 Sep;46(9):735-8. doi: 10.1590/1414-431X20132975. Epub 
      2013 Sep 27.