PMID- 24069820
OWN - NLM
STAT- MEDLINE
DCOM- 20150707
LR  - 20190918
IS  - 0042-8450 (Print)
IS  - 0042-8450 (Linking)
VI  - 70
IP  - 8
DP  - 2013 Aug
TI  - Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters 
      in patients with hypertension.
PG  - 728-34
AB  - BACKGROUND/AIM: Identification of patients with arterial hypertension and a 
      possible onset of heart failure by determining the concentration of N-terminal 
      pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of 
      treatment and allows clinicians to prescribe and implement optimal and 
      appropriate care. The aim of this study was to evaluate NT-proBNP in patients 
      with longstanding hypertension and in patients with signs of hypertensive 
      cardiomyopathy. METHODS: The study involved 3 groups, with 50 subjects each: 
      "healthy" persons (control group), patients with hypertension and normal left 
      ventricular systolic function (group 1) and patients with longstanding 
      hypertension and signs of hypertensive cardiomyopathy with impaired left 
      ventricular systolic function (group 2). We measured levels of NT-proBNP, 
      C-reactive protein and creatinine according to the manufacturer's instructions. 
      All the patients were clinically examined including physical examination of the 
      heart with blood pressure, pulse rate, electrocardiogram (ECG) and 
      echocardiogram. RESULTS: Our results showed that the determined parameters 
      generally differed significantly (Student's t-test) among the groups. The mean 
      (+/- SD) values of NT-proBNP in the control group, group 1 and group 2 were: 
      2.794 (+/- 1.515) pmol/L, 9.575 (+/- 5.449) pmol/L and 204.60 (84,93) pmol/L, 
      respectively. NT-proBNP correlated significantly with the determined parameters 
      both in the group 1 and the group 2. In the group 1, the highest correlation was 
      obtained with C-reactive protein (r = 0.8424). In the group 2, the highest 
      correlation was obtained with ejection fraction (r = -0.9111). NT-proBNP showed 
      progressive increase in proportion to the New York Heart Association (NYHA) 
      classification. The patients in the- group 2 who belonged to the II and III NYHA 
      class had significantly higher levels of NT-proBNP than those in the NYHA class I 
      (ANOVA test, p = 0.001). CONCLUSION: The obtained results suggest that NT-proBNP 
      is a useful biomarker in the treatment of patients with longstanding hypertension 
      who are at risk for heart failure.
FAU - Pejovic, Janko
AU  - Pejovic J
AD  - Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia. 
      jpejovic1962@gmail.com
FAU - Ignjatovic, Svetlana
AU  - Ignjatovic S
FAU - Dajak, Marijana
AU  - Dajak M
FAU - Majkic-Singh, Nada
AU  - Majkic-Singh N
FAU - Vucinic, Zarko
AU  - Vucinic Z
FAU - Pavlovic, Miroslav
AU  - Pavlovic M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Serbia
TA  - Vojnosanit Pregl
JT  - Vojnosanitetski pregled
JID - 21530700R
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Creatinine/blood
MH  - Echocardiography/methods
MH  - Electrocardiography/methods
MH  - Female
MH  - *Heart Failure/blood/diagnosis/etiology/physiopathology/prevention & control
MH  - Humans
MH  - *Hypertension/blood/complications
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Ventricular Dysfunction, Left/etiology/physiopathology
EDAT- 2013/09/28 06:00
MHDA- 2015/07/08 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2015/07/08 06:00 [medline]
AID - 10.2298/vsp110322048p [doi]
PST - ppublish
SO  - Vojnosanit Pregl. 2013 Aug;70(8):728-34. doi: 10.2298/vsp110322048p.