PMID- 24070068
OWN - NLM
STAT- MEDLINE
DCOM- 20140903
LR  - 20220318
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 36
IP  - 1
DP  - 2014 Jan
TI  - Factors associated with survival and recurrence for patients undergoing surgery 
      of cerebellar metastases.
PG  - 13-25
LID - 10.1179/1743132813Y.0000000260 [doi]
AB  - OBJECTIVE: Patients with cerebellar and non-cerebellar metastases are often 
      included in the same study population, even though posterior fossa lesions 
      typically have different presenting symptoms, clinical outcomes, and 
      complications. This is because the outcomes for patients with cerebellar 
      metastases are unclear. METHODS: Adult patients who underwent surgery for an 
      intracranial metastasis (single or multiple) between 2007 and 2011 were 
      retrospectively reviewed. Stepwise multivariate proportional hazards regression 
      analysis was used to identify an association between cerebellar location with 
      survival and recurrence. RESULTS: Of the 708 patients who underwent intracranial 
      metastatic surgery, 140 (19.8%) had surgery for cerebellar metastasis. A 
      cerebellar location was associated with poorer survival [RR (95% CI); 1.231 
      (1.016-1.523), P  =  0.04] and increased spinal recurrence [RR (95% CI); 2.895 
      (1.491-5.409), P  =  0.002], but not local (P  =  0.61) or distal recurrence (P 
       =  0.88). The factors independently associated with prolonged survival for 
      patients with cerebellar metastases were: decreasing number of intracranial 
      metastases (P  =  0.0002), decreasing tumor size (P  =  0.002), and radiation (P 
       =  0.0006). The factors associated with prolonged local progression free 
      survival were: decreasing tumor size (P  =  0.0009), non small cell lung cancer 
      (NSCLC) (P  =  0.006), non-bladder cancer (P  =  0.0005), and post-operative 
      radiation therapy (P  =  0.02). The factors independently associated with 
      prolonged distal progression free survival were: age > 40 years (P  =  0.02), 
      surgical resection (P  =  0.01), and whole brain radiation (WBRT) therapy (P  =  
      0.02). DISCUSSION: Patients with cerebellar metastases have more distinct 
      clinical presentations and outcomes than patients with non-cerebellar lesions. 
      The findings of this study may help risk stratify and guide treatment regimens 
      aimed at maximizing outcomes for patients with cerebellar metastases.
FAU - Chaichana, Kaisorn Lee
AU  - Chaichana KL
FAU - Rao, Karthik
AU  - Rao K
FAU - Gadkaree, Shekhar
AU  - Gadkaree S
FAU - Dangelmajer, Sean
AU  - Dangelmajer S
FAU - Bettegowda, Chetan
AU  - Bettegowda C
FAU - Rigamonti, Daniele
AU  - Rigamonti D
FAU - Weingart, Jon
AU  - Weingart J
FAU - Olivi, Alessandro
AU  - Olivi A
FAU - Gallia, Gary L
AU  - Gallia GL
FAU - Brem, Henry
AU  - Brem H
FAU - Lim, Michael
AU  - Lim M
FAU - Quinones-Hinojosa, Alfredo
AU  - Quinones-Hinojosa A
LA  - eng
PT  - Journal Article
DEP - 20131023
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Brain Neoplasms/secondary
MH  - Cerebellar Neoplasms/diagnosis/pathology/*secondary/*surgery
MH  - Cerebellum/pathology/surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neoplasms/pathology/therapy
MH  - Prognosis
MH  - Radiotherapy, Adjuvant
MH  - Recurrence
MH  - Retrospective Studies
MH  - Small Cell Lung Carcinoma/pathology
MH  - Spinal Cord Neoplasms/secondary
MH  - Treatment Outcome
MH  - Urinary Bladder Neoplasms/pathology
EDAT- 2013/09/28 06:00
MHDA- 2014/09/04 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2014/09/04 06:00 [medline]
AID - ner3144_1378729285824 [pii]
AID - 10.1179/1743132813Y.0000000260 [doi]
PST - ppublish
SO  - Neurol Res. 2014 Jan;36(1):13-25. doi: 10.1179/1743132813Y.0000000260. Epub 2013 
      Oct 23.