PMID- 24070185
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20220408
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 13
DP  - 2013 Sep 26
TI  - Association between obesity and Barrett's esophagus in a Japanese population: a 
      hospital-based, cross-sectional study.
PG  - 143
LID - 10.1186/1471-230X-13-143 [doi]
AB  - BACKGROUND: The association between obesity and Barrett's esophagus (BE) in the 
      Japanese population remains unclear. The prevalence of BE and its associated risk 
      factors was examined. METHODS: A cross-sectional study of 1581 consecutive 
      individuals who underwent upper gastrointestinal endoscopy was conducted. The 
      prevalence of endoscopically suspected BE (ESBE) was evaluated. Obesity was 
      evaluated by body mass index (BMI, >/= 25 kg/m2) and waist circumference (WC) 
      (males, >/= 85 cm; females, >/= 90 cm). Because endoscopic diagnosis of ultra-short 
      ESBE (<1 cm in extent) is difficult and highly unreliable, this type of ESBE was 
      excluded from the study. RESULTS: In proton pump inhibitor (PPI) non-users, the 
      prevalence of ESBE >/= 1 cm was 5.6%. In univariate analysis, male sex and reflux 
      esophagitis (RE) were significantly associated with BE, but BMI, WC, and reflux 
      symptoms were not. In multivariate logistic regression analysis, only RE (odds 
      ratio [OR] = 3.48, 95% confidence interval [CI] 1.89-6.41, p < 0.0001) was an 
      independent risk factor for BE; obesity and the other factors were not. In 
      contrast, RE (OR 5.67, p = 0.0004) and large WC (OR 5.09, p = 0.0005) were 
      significant risk factors for ESBE >/= 1 cm in PPI users. Only male sex, but not 
      obesity or the other risk factors, was associated with an increased risk of RE in 
      patients not taking PPIs. CONCLUSIONS: RE, but not obesity, may have an 
      independent association with the risk of ESBE in the Japanese population. 
      Furthermore, obesity measures were not independent risks for RE. Interestingly, 
      PPI-refractory RE and large WC were risk factors for ESBE >/=1 cm in patients 
      taking PPIs.
FAU - Watari, Jiro
AU  - Watari J
AD  - Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo 
      College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan. 
      watarij@hyo-med.ac.jp.
FAU - Hori, Kazutoshi
AU  - Hori K
FAU - Toyoshima, Fumihiko
AU  - Toyoshima F
FAU - Kamiya, Noriko
AU  - Kamiya N
FAU - Yamasaki, Takahisa
AU  - Yamasaki T
FAU - Okugawa, Takuya
AU  - Okugawa T
FAU - Asano, Haruki
AU  - Asano H
FAU - Li, Zhao Liang
AU  - Li ZL
FAU - Kondo, Takashi
AU  - Kondo T
FAU - Ikehara, Hisatomo
AU  - Ikehara H
FAU - Sakurai, Jun
AU  - Sakurai J
FAU - Tomita, Toshihiko
AU  - Tomita T
FAU - Oshima, Tadayuki
AU  - Oshima T
FAU - Fukui, Hirokazu
AU  - Fukui H
FAU - Miwa, Hiroto
AU  - Miwa H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130926
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Barrett Esophagus/*epidemiology
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Esophagitis, Peptic/*epidemiology
MH  - Esophagoscopy
MH  - Female
MH  - Gastroesophageal Reflux/epidemiology
MH  - Humans
MH  - Japan/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/*epidemiology
MH  - Obesity, Abdominal/epidemiology
MH  - Odds Ratio
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Risk Factors
MH  - Sex Factors
MH  - Waist Circumference
MH  - Young Adult
PMC - PMC3849380
EDAT- 2013/09/28 06:00
MHDA- 2014/04/02 06:00
PMCR- 2013/09/26
CRDT- 2013/09/28 06:00
PHST- 2013/03/17 00:00 [received]
PHST- 2013/09/20 00:00 [accepted]
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
PHST- 2013/09/26 00:00 [pmc-release]
AID - 1471-230X-13-143 [pii]
AID - 10.1186/1471-230X-13-143 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2013 Sep 26;13:143. doi: 10.1186/1471-230X-13-143.