PMID- 24070385
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20130927
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 120
DP  - 2013
TI  - Terminal differentiation of dendritic cells.
PG  - 185-210
LID - B978-0-12-417028-5.00007-7 [pii]
LID - 10.1016/B978-0-12-417028-5.00007-7 [doi]
AB  - Dendritic cells (DCs) are essential for the initiation of an effective immune 
      response. Despite this, our understanding of the molecular regulation of this 
      important cell type has lagged significantly behind that of other lymphoid 
      populations such as B and T cells, but recent development of various tools has 
      greatly facilitated progress in the field. Here, we review the transcription 
      factors that drive peripheral DC subset fate decisions. While Pu.1, Ikaros, and 
      Gfi-1 are essential for precursor DCs to give rise to monocytes, conventional 
      DCs, and plasmacytoid DCs, the balance between E2-2 and Id2 directs committed 
      precursors along a pDC or cDC lineage, respectively. Several transcription 
      factors such as Batf3, Nfil3, and Id2 are required for different DC subsets at 
      steady-state and drive segregation into the individual DCs subsets late in 
      development in the CD8 lineage. During inflammation, CD8-expressing DCs emerge 
      that feature many of the hallmarks of classical CD8alpha(+) DCs but surprisingly do 
      not depend on the same transcription factors. Thus, the immune system has 
      developed two pathways of DC differentiation that enable it to maintain 
      homeostatic balance and to respond rapidly to the emergency requirement for DCs 
      that might occur during infection.
CI  - (c) 2013 Elsevier Inc. All rights reserved.
FAU - Seillet, Cyril
AU  - Seillet C
AD  - Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical 
      Research, Melbourne, Victoria, Australia; Department of Medical Biology, 
      University of Melbourne, Melbourne, Victoria, Australia.
FAU - Belz, Gabrielle T
AU  - Belz GT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - *Cell Differentiation
MH  - Dendritic Cells/classification/*cytology/immunology/metabolism
MH  - Humans
MH  - Transcription Factors/metabolism
OTO - NOTNLM
OT  - Antigen presenting cells
OT  - Dendritic cells
OT  - Differentiation
OT  - Immunity
OT  - Transcription factors
EDAT- 2013/09/28 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - B978-0-12-417028-5.00007-7 [pii]
AID - 10.1016/B978-0-12-417028-5.00007-7 [doi]
PST - ppublish
SO  - Adv Immunol. 2013;120:185-210. doi: 10.1016/B978-0-12-417028-5.00007-7.