PMID- 24070386
OWN - NLM
STAT- MEDLINE
DCOM- 20131217
LR  - 20130927
IS  - 1557-8445 (Electronic)
IS  - 0065-2776 (Linking)
VI  - 120
DP  - 2013
TI  - Diversity of pathogen sensors in dendritic cells.
PG  - 211-37
LID - B978-0-12-417028-5.00008-9 [pii]
LID - 10.1016/B978-0-12-417028-5.00008-9 [doi]
AB  - Dendritic cells (DCs) associate the capacity to sense pathogens with the 
      initiation of adaptive immunity. Pathogens can be sensed through 
      pathogen-associated molecular patterns by pathogen-recognition receptors 
      expressed on host cells. Pathogen-encoded activities can also be sensed when they 
      modify normal host cellular processes. The diversity of pathogen sensors has been 
      highlighted by the identification of several cytosolic sensors involved in the 
      recognition of nucleic acids from pathogens. The number of these pathogen 
      cytosolic sensors has dramatically increased recently. Different DC populations 
      appear to be equipped with distinct sensors but the precise expression pattern 
      and the regulation of these sensors remain to be established, especially in 
      humans. The engagement of sensors in DCs by pathogens leads to antipathogen 
      effects through multiple mechanisms including interferon responses and promotes 
      effector pathways that can shape the adaptive immune response. How the diversity 
      of cytosolic pathogen sensors impacts these processes is incompletely understood. 
      Investigating the expression, regulation, and crosstalk of the sensors should 
      shed light on how pathogen sensing impacts pathogen replication and host immune 
      responses.
CI  - (c) 2013 Elsevier Inc. All rights reserved.
FAU - Cerboni, Silvia
AU  - Cerboni S
AD  - Institut Curie, 12 rue Lhomond, Paris, France; INSERM U932, 12 rue Lhomond, 
      Paris, France.
FAU - Gentili, Matteo
AU  - Gentili M
FAU - Manel, Nicolas
AU  - Manel N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/metabolism
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Receptors, Pattern Recognition/metabolism
MH  - Viruses/pathogenicity
OTO - NOTNLM
OT  - Adaptive immunity
OT  - DC subsets
OT  - DNA sensors
OT  - Dendritic cells
OT  - HIV
OT  - Innate immunity
OT  - Pathogen sensors
OT  - RNA sensors
OT  - Type I interferon
EDAT- 2013/09/28 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - B978-0-12-417028-5.00008-9 [pii]
AID - 10.1016/B978-0-12-417028-5.00008-9 [doi]
PST - ppublish
SO  - Adv Immunol. 2013;120:211-37. doi: 10.1016/B978-0-12-417028-5.00008-9.