PMID- 24070857
OWN - NLM
STAT- MEDLINE
DCOM- 20140625
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 257
DP  - 2013 Nov 15
TI  - 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice.
PG  - 8-12
LID - S0166-4328(13)00579-2 [pii]
LID - 10.1016/j.bbr.2013.09.029 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a crucial regulator of neuronal 
      survival and neuroplasticity in the central nervous system (CNS). As a result, 
      there has been a growing interest in the role of BDNF in neuropsychiatric 
      disorders associated with neurodegeneration, including depression and dementia. 
      However, until now, BDNF-targeting therapies have yielded disappointing results. 
      BDNF is thought to exert its beneficial effects on synaptic and neuronal 
      plasticity mainly through binding to the tyrosine kinase B (TrkB) receptor. 
      Recently, 7,8-dihydroxyflavone (7,8-DHF) was identified as the first selective 
      TrkB agonist. In the present study the effect of 7,8-DHF on memory consolidation 
      processes was evaluated. In healthy rats, 7,8-DHF improved object memory 
      formation in the object recognition task when administered both immediately and 
      3h after learning. In a transgenic mouse model of Alzheimer's disease, i.e. 
      APPswe/PS1dE9 mice, spatial memory as measured in the object location task was 
      improved after administration of 7,8-DHF. A similar memory improvement was found 
      when their wild-type littermates were treated with 7,8-DHF. The acute beneficial 
      effects in healthy mice suggest that effects might be symptomatic rather than 
      curing. Nevertheless, this study suggests that 7,8-DHF might be a promising 
      therapeutic target for dementia.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Bollen, E
AU  - Bollen E
AD  - Department of Psychiatry and Neuropsychology, School of Mental Health and 
      Neuroscience, Maastricht University, The Netherlands.
FAU - Vanmierlo, T
AU  - Vanmierlo T
FAU - Akkerman, S
AU  - Akkerman S
FAU - Wouters, C
AU  - Wouters C
FAU - Steinbusch, H M W
AU  - Steinbusch HM
FAU - Prickaerts, J
AU  - Prickaerts J
LA  - eng
PT  - Journal Article
DEP - 20130923
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (7,8-dihydroxyflavanone)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Flavanones)
RN  - 0 (PSEN1 protein, human)
RN  - 0 (Presenilin-1)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Alzheimer Disease/complications/genetics
MH  - Amyloid beta-Protein Precursor/genetics
MH  - Animals
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Flavanones/*therapeutic use
MH  - Humans
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*drug therapy/etiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Mutation/genetics
MH  - Presenilin-1/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*agonists
MH  - Recognition, Psychology/drug effects
OTO - NOTNLM
OT  - 7,8-DHF
OT  - 7,8-Dihydroxyflavone
OT  - 7,8-dihydroxyflavone
OT  - AD
OT  - Alzheimer's disease
OT  - Abeta
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - CNS
OT  - CREB
OT  - Ca(2+)/calmodulin-dependent protein kinase II
OT  - CaMKII
OT  - Cognition enhancers
OT  - LTP
OT  - Memory consolidation
OT  - N-methyl-d-aspartic acid
OT  - NMDA
OT  - OLT
OT  - ORT
OT  - PTSD
OT  - T1
OT  - T2
OT  - TrkB
OT  - TrkB receptor
OT  - WT
OT  - amyloid beta
OT  - brain-derived neurotrophic factor
OT  - cAMP-responsive element binding
OT  - central nervous system
OT  - first trial
OT  - i.p.
OT  - intraperitoneal
OT  - long-term potentiation
OT  - mBDNF
OT  - mature BDNF
OT  - object location task
OT  - object recognition task
OT  - p.o.
OT  - per os
OT  - post-traumatic stress disorder
OT  - precursor of BDNF
OT  - proBDNF
OT  - second trial
OT  - tyrosine kinase B
OT  - wild-type
EDAT- 2013/09/28 06:00
MHDA- 2014/06/26 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/07/19 00:00 [received]
PHST- 2013/09/08 00:00 [revised]
PHST- 2013/09/13 00:00 [accepted]
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2014/06/26 06:00 [medline]
AID - S0166-4328(13)00579-2 [pii]
AID - 10.1016/j.bbr.2013.09.029 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Nov 15;257:8-12. doi: 10.1016/j.bbr.2013.09.029. Epub 2013 
      Sep 23.