PMID- 24071958
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20220409
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 54
IP  - 10
DP  - 2013 Oct 29
TI  - Reticular pseudodrusen in early age-related macular degeneration are associated 
      with choroidal thinning.
PG  - 7075-81
LID - 10.1167/iovs.13-12474 [doi]
AB  - PURPOSE: To compare choroidal thickness (CT) measurements in early AMD between 
      patients with and without reticular pseudodrusen (RPD) using spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: This cross-sectional study 
      examined 84 age- and sex-matched AMD patients (40 RPD [63 eyes], 44 non-RPD [75 
      eyes]). Fundus photographs and scanning laser ophthalmoscopy images were graded 
      to identify RPD and non-RPD groups by three retinal specialists (MO, SY, SB) who 
      were masked to corresponding SD-OCTs. CT at the fovea and 2400 to 3000 mum 
      superior and inferior to the fovea was measured on SD-OCT by a grader (AG) and 
      reviewed by a retinal specialist (SB). Only images with a clear posterior 
      choroidal margin were analyzed (six eyes excluded due to poor image quality), and 
      enhanced depth imaging SD-OCT was used when available (20 of 138 eyes). Greatest 
      retinal thickness (RT) on horizontal foveal SD-OCT was also recorded. RESULTS: 
      Mean CTs in the superior, foveal, and inferior macula in RPD (191.3 mum +/- 57.9 SD, 
      176.3 mum +/- 60.5 SD, 179.7 mum +/- 56.24 SD) were significantly less than that of 
      non-RPD (228.0 mum +/- 66.1 SD, 216.5 mum +/- 70.3 SD, 224.4 mum +/- 71.9 SD; P = 0.0010, 
      P = 0.0005, P = 0.0001, respectively), as was greatest RT (P = 0.0301). 
      CONCLUSIONS: CT was thinner throughout the macula in the RPD group as compared 
      with the non-RPD group. The current analysis supports an association between RPD 
      and a thinned choroidal layer and is consistent with a choroidal etiology of RPD. 
      CT may be integral to understanding RPD, and may be helpful in stratifying AMD 
      progression risk.
FAU - Garg, Aakriti
AU  - Garg A
AD  - Department of Ophthalmology, Columbia University College of Physicians and 
      Surgeons, New York, New York.
FAU - Oll, Maris
AU  - Oll M
FAU - Yzer, Suzanne
AU  - Yzer S
FAU - Chang, Stanley
AU  - Chang S
FAU - Barile, Gaetano R
AU  - Barile GR
FAU - Merriam, John C
AU  - Merriam JC
FAU - Tsang, Stephen H
AU  - Tsang SH
FAU - Bearelly, Srilaxmi
AU  - Bearelly S
LA  - eng
GR  - R01 EY018213/EY/NEI NIH HHS/United States
GR  - T35 HL007616/HL/NHLBI NIH HHS/United States
GR  - R01EY018213/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20131029
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*pathology
MH  - Choroid Diseases/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis
MH  - Humans
MH  - Macular Degeneration/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Drusen/*pathology
MH  - Tomography, Optical Coherence/methods
PMC - PMC3813319
OTO - NOTNLM
OT  - choroidal layer
OT  - early age-related macular degeneration
OT  - reticular pseudodrusen
OT  - retinal ischemia
OT  - spectral-domain optical coherence tomography
EDAT- 2013/09/28 06:00
MHDA- 2013/12/18 06:00
PMCR- 2014/04/01
CRDT- 2013/09/28 06:00
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - iovs.13-12474 [pii]
AID - 10.1167/iovs.13-12474 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2013 Oct 29;54(10):7075-81. doi: 
      10.1167/iovs.13-12474.