PMID- 24071970
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20211021
IS  - 1432-2099 (Electronic)
IS  - 0301-634X (Linking)
VI  - 53
IP  - 1
DP  - 2014 Mar
TI  - Late effects of local irradiation on the expression of inflammatory markers in 
      the Arteria saphena of C57BL/6 wild-type and ApoE-knockout mice.
PG  - 117-24
LID - 10.1007/s00411-013-0492-7 [doi]
AB  - Combined action of irradiation (IR), shear stress, and high blood pressure is 
      well recognized to induce damage to vasculature, while data on pathological 
      effects of IR in large peripheral vessels with low blood pressure are scarce. The 
      purpose of the present study was hence to investigate time- and dose-dependent 
      effects of local IR on inflammatory and prothrombotic processes in the Arteria 
      (A.) saphena of C57BL/6 wild-type and apolipoprotein E (ApoE)-knockout mice. 
      Single doses of 2, 5, 8, 10, or 16 Gy were locally delivered to the A. saphena of 
      the left leg of the animals. The expression of CD31, intercellular adhesion 
      molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, 
      monocyte chemoattractant protein-1 (MCP-1), and thrombomodulin (TM) was 
      quantified by semiautomatic TissueFax fluorescence analysis in frozen arterial 
      sections. Follow-up periods were 3, 6, 9, 12, or 18 months. Protein expression in 
      the arterial wall displayed dose-dependent changes. Proinflammatory reactions 
      were observed for CD31, E-selectin, ICAM, and VCAM already at doses of 2 Gy. 
      Anti-inflammatory changes were detected for MCP-1 and TM. The effects were more 
      pronounced in wild-type versus ApoE(-/-) mice. Changes remain mostly transient up 
      to 16 Gy. Dose- and time-dependent changes in inflammatory and thrombotic 
      mediators in the wall of the A. saphena were found after local IR but did not 
      transform into histopathological consequences.
FAU - Patties, I
AU  - Patties I
AD  - Department of Radiation Therapy, University of Leipzig, Stephanstrasse 9a, 04103, 
      Leipzig, Germany.
FAU - Habelt, B
AU  - Habelt B
FAU - Rosin, B
AU  - Rosin B
FAU - Dorr, W
AU  - Dorr W
FAU - Hildebrandt, G
AU  - Hildebrandt G
FAU - Glasow, A
AU  - Glasow A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130927
PL  - Germany
TA  - Radiat Environ Biophys
JT  - Radiation and environmental biophysics
JID - 0415677
RN  - 0 (Apolipoproteins E)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Apolipoproteins E/*deficiency/*genetics
MH  - Arteries/*metabolism/*radiation effects
MH  - Biomarkers/metabolism
MH  - Gene Expression Regulation/*radiation effects
MH  - Inflammation/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Time Factors
EDAT- 2013/09/28 06:00
MHDA- 2015/01/30 06:00
CRDT- 2013/09/28 06:00
PHST- 2013/03/20 00:00 [received]
PHST- 2013/09/10 00:00 [accepted]
PHST- 2013/09/28 06:00 [entrez]
PHST- 2013/09/28 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - 10.1007/s00411-013-0492-7 [doi]
PST - ppublish
SO  - Radiat Environ Biophys. 2014 Mar;53(1):117-24. doi: 10.1007/s00411-013-0492-7. 
      Epub 2013 Sep 27.