PMID- 24073857
OWN - NLM
STAT- MEDLINE
DCOM- 20140908
LR  - 20171116
IS  - 1744-5116 (Electronic)
IS  - 1388-0209 (Linking)
VI  - 52
IP  - 1
DP  - 2014 Jan
TI  - Protective effect of Basella alba and Carpolobia alba extracts against 
      maneb-induced male infertility.
PG  - 97-104
LID - 10.3109/13880209.2013.816860 [doi]
AB  - CONTEXT: Male infertility is one of the leading causes of social frustration and 
      marginalization, mainly in the developing world. It is attributed to many factors 
      including exposure to agropesticides such as manganese ethylenebis 
      (dithiocarbamate) (maneb), which is one of the most frequently used fungicides in 
      Cameroon. Previous reports support efficiency of some medicinal plants commonly 
      used in Cameroonian folk medicine for the treatment of this disorder. OBJECTIVE: 
      The present study was aimed at assessing the protective effect of extracts from 
      selected plant species, namely Basella alba L. (Basellaceae) (MEBa) and 
      Carpolobia alba G. Don (Polygalaceae) (AECa), in alleviating the maneb-induced 
      impairment of male reproductive function in Wistar albino rats. MATERIALS AND 
      METHODS: The rats were treated with vehicle, plant extract (MEBa or AECa), maneb 
      and maneb plus plant extract, respectively, and their fertility was assessed. 
      Animals were thereafter sacrificed and organs (liver, kidneys and reproductive 
      organs) were dissected out and weighed. Serum androgens together with alanine 
      aminotransferase, liver glutathione and thiobarbituric acid reactive species 
      (TBARS) were also measured. RESULTS AND DISCUSSION: From this study, both plant 
      extracts stimulated testosterone and improved fertility. Administration of MEBa 
      plus maneb prevented fertility reduction by maneb and minimized the inhibitory 
      effect of maneb on testosterone levels. AECa also improved fertility of the 
      maneb-exposed rats, though without restoring testosterone levels, and other 
      investigated parameters remained unaffected by different treatments. CONCLUSION: 
      These findings emphasized the beneficial effects of B. alba and C. alba extracts 
      on male fertility, and suggest their protective effect against maneb-induced 
      toxicity in male reproductive function.
FAU - Manfo, Faustin Pascal Tsague
AU  - Manfo FP
AD  - Department of Biochemistry and Molecular Biology, Faculty of Science, University 
      of Buea , Buea , Cameroon .
FAU - Nantia, Edouard Akono
AU  - Nantia EA
FAU - Dechaud, Henri
AU  - Dechaud H
FAU - Tchana, Angele Nkouatchoua
AU  - Tchana AN
FAU - Zabot, Marie-Therese
AU  - Zabot MT
FAU - Pugeat, Michel
AU  - Pugeat M
FAU - Moundipa, Paul Fewou
AU  - Moundipa PF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130930
PL  - England
TA  - Pharm Biol
JT  - Pharmaceutical biology
JID - 9812552
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Plant Extracts)
RN  - 12427-38-2 (Maneb)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Cameroon
MH  - Disease Models, Animal
MH  - Fungicides, Industrial/toxicity
MH  - Infertility, Male/*prevention & control
MH  - Magnoliopsida/*chemistry
MH  - Male
MH  - Maneb/toxicity
MH  - Medicine, Traditional
MH  - Plant Extracts/*pharmacology
MH  - Polygalaceae/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Testosterone/blood
EDAT- 2013/10/01 06:00
MHDA- 2014/09/10 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - 10.3109/13880209.2013.816860 [doi]
PST - ppublish
SO  - Pharm Biol. 2014 Jan;52(1):97-104. doi: 10.3109/13880209.2013.816860. Epub 2013 
      Sep 30.