PMID- 24076050
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20211021
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 39
IP  - 4
DP  - 2013 Oct 17
TI  - Control of T helper 2 responses by transcription factor IRF4-dependent dendritic 
      cells.
PG  - 722-32
LID - S1074-7613(13)00380-4 [pii]
LID - 10.1016/j.immuni.2013.08.028 [doi]
AB  - CD4(+) T cell differentiation is regulated by specialized antigen-presenting cells. 
      Dendritic cells (DCs) produce cytokines that promote naive CD4(+) T cell 
      differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) 
      cells. However, the initiation of Th2 cell responses remains poorly understood, 
      although it is likely that more than one mechanism might be involved. Here we 
      have defined a specific DC subset that is involved in Th2 cell differentiation in 
      vivo in response to a protease allergen, as well as infection with 
      Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled 
      by the transcription factor interferon regulatory factor 4 (IRF4), which is 
      required for their differentiation and Th2 cell-inducing function. IRF4 is known 
      to control Th2 cell differentiation and Th2 cell-associated suppressing function 
      in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it 
      controls the initiation of Th2 cell responses.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Gao, Yan
AU  - Gao Y
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, CT 
      06520, USA; Department of Cell Biology, Yale University School of Medicine, New 
      Haven, CT 06520, USA.
FAU - Nish, Simone A
AU  - Nish SA
FAU - Jiang, Ruoyi
AU  - Jiang R
FAU - Hou, Lin
AU  - Hou L
FAU - Licona-Limon, Paula
AU  - Licona-Limon P
FAU - Weinstein, Jason S
AU  - Weinstein JS
FAU - Zhao, Hongyu
AU  - Zhao H
FAU - Medzhitov, Ruslan
AU  - Medzhitov R
LA  - eng
GR  - R01 AI089771/AI/NIAID NIH HHS/United States
GR  - R01 AI08977/AI/NIAID NIH HHS/United States
GR  - R01 AI055502/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - T32 AR007107/AR/NIAMS NIH HHS/United States
GR  - R37 AI046688/AI/NIAID NIH HHS/United States
GR  - 5R01 AI055502/AI/NIAID NIH HHS/United States
GR  - R01 AI046688/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130926
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Allergens)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (interferon regulatory factor-4)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
CIN - Nat Rev Immunol. 2013 Dec;13(12):844-5. PMID: 24136622
MH  - Allergens/immunology
MH  - Animals
MH  - Bone Marrow Cells/cytology/immunology/parasitology
MH  - Cell Differentiation
MH  - Coculture Techniques
MH  - Dendritic Cells/*immunology/parasitology/pathology
MH  - Gene Expression Regulation
MH  - *Immunity, Cellular
MH  - Interferon Regulatory Factors/genetics/*immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Nippostrongylus/immunology
MH  - Ovalbumin/immunology
MH  - Signal Transduction
MH  - Strongylida Infections/*immunology/parasitology/pathology
MH  - T-Lymphocytes, Regulatory/immunology/parasitology/pathology
MH  - Th1 Cells/immunology/parasitology/pathology
MH  - Th2 Cells/*immunology/parasitology/pathology
PMC - PMC4110745
MID - NIHMS597920
EDAT- 2013/10/01 06:00
MHDA- 2013/12/18 06:00
PMCR- 2014/10/17
CRDT- 2013/10/01 06:00
PHST- 2013/01/15 00:00 [received]
PHST- 2013/07/29 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2014/10/17 00:00 [pmc-release]
AID - S1074-7613(13)00380-4 [pii]
AID - 10.1016/j.immuni.2013.08.028 [doi]
PST - ppublish
SO  - Immunity. 2013 Oct 17;39(4):722-32. doi: 10.1016/j.immuni.2013.08.028. Epub 2013 
      Sep 26.