PMID- 24076087
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20211203
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 254
DP  - 2013 Dec 19
TI  - Chronic binge-like alcohol consumption in adolescence causes depression-like 
      symptoms possibly mediated by the effects of BDNF on neurogenesis.
PG  - 324-34
LID - S0306-4522(13)00803-8 [pii]
LID - 10.1016/j.neuroscience.2013.09.031 [doi]
AB  - Here we investigated whether changes in neurogenesis and brain-derived 
      neurotrophic factor (BDNF) expression are possible mechanisms involved in the 
      depression-like symptom during the withdrawal/abstinence period after chronic 
      binge-pattern alcohol consumption given the limited number of studies addressing 
      the link between these factors in the adolescent brain. Forty-seven male 
      Sprague-Dawley rats were used in the study and the experimental protocol started 
      when rats were 25-days old. Rats were assigned to either: (a) ethanol or (b) 
      control group. Animals in each group were further randomized to receive either: 
      BDNF receptor agonist or vehicle. Rats were trained to self-administer ethanol 
      and the binge protocol consisted of daily 30-min experimental sessions 4h into 
      the dark period for 12days. Two days after the last drinking session, rats were 
      tested in the sucrose preference test to evaluate anhedonia and the open field 
      test after habituation to evaluate behavioral despair. Our data showed that: (1) 
      self-administration of alcohol in a binge-like pattern causes inebriation as 
      defined by the National Institute on Alcohol Abuse and Alcoholism and this 
      pattern of alcohol exposure is associated with the development of a 
      depression-like symptom; (2) no significant difference in blood alcohol levels 
      between the two ethanol groups; and (3) chronic binge drinking resulted in the 
      development of a depressive phenotype, decreased survival and neuronal 
      differentiation of neural progenitor cells in the hippocampus, and decreased BDNF 
      effect during the withdrawal period. But the most important finding in our study 
      is that augmenting BDNF actions through the use of tyrosine kinase B (TrkB, a 
      BDNF receptor) agonist restored neurogenesis and abolished the alcohol-induced 
      anhedonia and despair behaviors seen during the withdrawal/abstinence period. Our 
      results suggest that BDNF might be a molecule that can be targeted for 
      interventions in alcoholism-depression co-incidence.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Briones, T L
AU  - Briones TL
AD  - Department of Adult Health, Wayne State University, Detroit, MI 48202, USA. 
      Electronic address: tbriones@wayne.edu.
FAU - Woods, J
AU  - Woods J
LA  - eng
GR  - R01 NR007666/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130925
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Age Factors
MH  - Alcohol Drinking/metabolism/psychology
MH  - Animals
MH  - Binge Drinking/*metabolism/psychology
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*physiology
MH  - Depression/*metabolism/psychology
MH  - Doublecortin Protein
MH  - Ethanol/administration & dosage
MH  - Male
MH  - Neurogenesis/drug effects/*physiology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/agonists/biosynthesis/physiology
MH  - Self Administration
PMC - PMC3983287
MID - NIHMS527829
OTO - NOTNLM
OT  - 7,8-DHF
OT  - 7,8-dihydroflavone
OT  - ANOVA
OT  - BCA
OT  - BDNF
OT  - BrdU
OT  - Bromodeoxyuridine
OT  - DCX
OT  - DMSO
OT  - EDTA
OT  - ELISA
OT  - IgG
OT  - NIAAA
OT  - NPC
OT  - National Institute on Alcohol Abuse and Alcoholism
OT  - SSC
OT  - TBS
OT  - TBS-TS
OT  - TBS/0.1% Triton X-100/3% donkey serum
OT  - Tris-buffered saline
OT  - TrkB
OT  - analysis of variance
OT  - bicinchoninic acid
OT  - brain-derived neurotrophic factor
OT  - dimethyl sulfoxide
OT  - doublecortin
OT  - enzyme-linked immunosorbent assay
OT  - ethylenediaminetetraacetic acid
OT  - hippocampus
OT  - i.p.
OT  - immunoglobulin G
OT  - immunohistochemistry
OT  - intraperitoneally
OT  - neural progenitor cell
OT  - open field test
OT  - saline-sodium citrate buffer
OT  - sucrose preference test
OT  - tyrosine kinase B
EDAT- 2013/10/01 06:00
MHDA- 2015/02/24 06:00
PMCR- 2014/12/19
CRDT- 2013/10/01 06:00
PHST- 2013/06/16 00:00 [received]
PHST- 2013/09/16 00:00 [revised]
PHST- 2013/09/16 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
PHST- 2014/12/19 00:00 [pmc-release]
AID - S0306-4522(13)00803-8 [pii]
AID - 10.1016/j.neuroscience.2013.09.031 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Dec 19;254:324-34. doi: 10.1016/j.neuroscience.2013.09.031. 
      Epub 2013 Sep 25.