PMID- 24076209
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20220321
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1538
DP  - 2013 Nov 13
TI  - Evidence for a medial prefrontal cortex-hippocampal axis associated with heart 
      rate control in conscious humans.
PG  - 104-15
LID - S0006-8993(13)01306-1 [pii]
LID - 10.1016/j.brainres.2013.09.032 [doi]
AB  - Cardiovascular arousal correlates to activity within the medial prefrontal cortex 
      (MPFC). Additional evidence provides anatomical and functional links between the 
      MPFC and hippocampus (HC). This study tested the hypothesis that the MPFC and HC 
      form a sub-network associated with rapid heart rate (HR) responses to volitional 
      effort. Primary analyses were performed on 29 individuals (18 males) ranging from 
      21 to 80 years of age, who produced a HR response >3bpm to an isometric handgrip 
      (IHG) task. HR and cortical activity were recorded using functional magnetic 
      resonance imaging with blood oxygen level-dependent contrast. The average change 
      in HR from baseline was 6bpm +/-2. Activity in the MPFC and left HC was reduced 
      relative to baseline in all subjects when correlated with the HR time course. 
      Measures of connectivity demonstrated that the MPFC engaged in significantly 
      stronger functional connectivity to the left HC during a 40% IHG task. Effective 
      connectivity revealed a directionality of influence from the MPFC to the left HC. 
      A second group (n=15) of individuals without a HR response (~1bpm) to IHG were 
      studied post-hoc and these individuals showed no deactivation in either the MPFC 
      or left HC. These results suggest the presence of a MPFC-HC axis that 
      participates in the neurally-mediated HR response to exercise.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Norton, Katelyn N
AU  - Norton KN
AD  - Neurovascular Research Laboratory, School of Kinesiology, The University of 
      Western Ontario, London, Ontario, Canada N6A 3K7.
FAU - Luchyshyn, Torri A
AU  - Luchyshyn TA
FAU - Kevin Shoemaker, J
AU  - Kevin Shoemaker J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130927
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Mapping
MH  - Female
MH  - Hand Strength/physiology
MH  - Heart Rate/*physiology
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/physiology
MH  - Prefrontal Cortex/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cortical autonomic network
OT  - Heart rate control
OT  - Limbic system
EDAT- 2013/10/01 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/06/25 00:00 [received]
PHST- 2013/09/17 00:00 [revised]
PHST- 2013/09/23 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - S0006-8993(13)01306-1 [pii]
AID - 10.1016/j.brainres.2013.09.032 [doi]
PST - ppublish
SO  - Brain Res. 2013 Nov 13;1538:104-15. doi: 10.1016/j.brainres.2013.09.032. Epub 
      2013 Sep 27.