PMID- 24076518
OWN - NLM
STAT- MEDLINE
DCOM- 20140723
LR  - 20220331
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 31
IP  - 8
DP  - 2013 Dec
TI  - Differential expression of human placental neurotrophic factors in preterm and 
      term deliveries.
PG  - 719-23
LID - S0736-5748(13)00134-2 [pii]
LID - 10.1016/j.ijdevneu.2013.09.006 [doi]
AB  - Neurotrophic factors such as brain derived neurotrophic factor (BDNF) and nerve 
      growth factor (NGF) are involved in development of the placenta and fetal brain. 
      A series of human and animal studies in our department have shown that 
      micronutrients (folic acid, vitamin B12) and omega 3 fatty acids like DHA are all 
      interlinked in the one carbon cycle. Any alterations in one carbon components 
      will lead to changes in methylation patterns that further affect the gene 
      expression at critical periods of development resulting in complications during 
      pregnancy. This may further contribute to risk for neurodevelopmental disorders 
      in children born preterm. Therefore this study for the first time examines the 
      mRNA levels from preterm and term placentae. A total number of 38 women 
      delivering preterm (<37 weeks gestation) and 37 women delivering at term (=>37 
      weeks gestation) were recruited. The mRNA levels of BDNF and NGF were analyzed by 
      real time quantitative polymerase chain reaction. Our results indicate that BDNF 
      and NGF mRNA levels were lower in preterm group as compared to term group. There 
      was a positive association of placental BDNF and NGF mRNA levels with cord plasma 
      BDNF and NGF levels. The differential expression of BDNF and NGF gene in preterm 
      placentae may also alter the vascular development in preterm deliveries. Our data 
      suggests that the reduced mRNA levels of BDNF and NGF may possibly be a result of 
      altered epigenetic mechanisms and may have an implication for altered fetal 
      programming in children born preterm.
CI  - Copyright (c) 2013 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Dhobale, Madhavi V
AU  - Dhobale MV
AD  - Department of Nutritional Medicine, Interactive Research School for Health 
      Affairs, Bharati Vidyapeeth University, Pune 411043, India.
FAU - Pisal, Hemlata R
AU  - Pisal HR
FAU - Mehendale, Savita S
AU  - Mehendale SS
FAU - Joshi, Sadhana R
AU  - Joshi SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130926
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Female
MH  - Humans
MH  - Nerve Growth Factor/genetics/*metabolism
MH  - Placenta/*metabolism
MH  - Pregnancy
MH  - Premature Birth/*physiopathology
MH  - RNA, Messenger/metabolism
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - ADHD
OT  - BDNF
OT  - BMI
OT  - Brain derived neurotrophic factor
OT  - DEPC
OT  - DHA
OT  - Epigenetics
OT  - GAPDH
OT  - MAPK/ERK
OT  - Methylation
OT  - NGF
OT  - Nerve growth factor and placenta
OT  - PI3k
OT  - PKB
OT  - attention deficit hyperactivity disorder
OT  - body mass index
OT  - brain derived neurotrophic factor
OT  - diethyl pyrocarbonate
OT  - docosahexaenoic acid
OT  - glyceraldehyde 3-phosphate dehydrogenase
OT  - mitogen-activated protein kinases/extracellular signal-regulated kinases
OT  - nerve growth factor
OT  - phosphatidylinositol 3-kinase pathway
OT  - protein kinase B
EDAT- 2013/10/01 06:00
MHDA- 2014/07/24 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/08/19 00:00 [revised]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/07/24 06:00 [medline]
AID - S0736-5748(13)00134-2 [pii]
AID - 10.1016/j.ijdevneu.2013.09.006 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2013 Dec;31(8):719-23. doi: 10.1016/j.ijdevneu.2013.09.006. 
      Epub 2013 Sep 26.