PMID- 24078164
OWN - NLM
STAT- MEDLINE
DCOM- 20140611
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 40
IP  - 11
DP  - 2013 Nov
TI  - Circulating C5L2 gene polymorphism is associated with type 2 diabetes mellitus in 
      Saudi population.
PG  - 6323-7
AB  - The aim of the present study was to examine the relationship between the novel 
      single nucleotide polymorphism, 698C>T that causes an amino acid change from 
      proline to leucine at codon 233 and type 2 diabetes mellitus (T2DM) in the Saudi 
      population. From the general population in the Saudi Arabia a total of 551 
      samples were collected and categorized them as T2DM (n = 376) and healthy 
      controls (n = 175). Five ml of the blood sample was collected and used for the 
      Biochemical and Molecular analysis. With the help of serum sample lipid profile: 
      Fasting blood sugar (FBS), Total Cholesterol (TC), Triglycerides (TG), High 
      Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol 
      (LDL-C) and VLDL were performed. PCR-RFLP was performed after separating the 
      genomic DNA from the EDTA blood. The genotype distribution of C698T polymorphism 
      was performed by the Chi square test with SPSS version 16.0 software for 
      comparing T2DM subjects and healthy controls. In our study, genotypic 
      distributions of C5L2 C698T polymorphism and allele frequency of patients and 
      controls were found to be significant difference in the allele and the genotypic 
      distribution. [For T Vs C; p = 0.01; Odds ratio = 3.594 (95 % CI; 1.256-10.28); 
      and CT+TT Vs CC; p = 0.009; Odds ratio = 3.707 (95 % CI; 1.285-10.69)]. TT 
      genotype was completely absent in both the cases and the controls. In conclusion, 
      our study indicates that 698C>T polymorphism of C5L2 gene is associated with the 
      T2DM in individuals of Saudi population which was found to be similar with other 
      studies.
FAU - Alharbi, Khalid K
AU  - Alharbi KK
FAU - Khan, Imran Ali
AU  - Khan IA
FAU - Syed, Rabbani
AU  - Syed R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (C5aR2 protein, human)
RN  - 0 (Receptor, Anaphylatoxin C5a)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Anaphylatoxin C5a
MH  - Receptors, Chemokine/*genetics
MH  - Risk Factors
MH  - Saudi Arabia
EDAT- 2013/10/01 06:00
MHDA- 2014/06/12 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/02/13 00:00 [received]
PHST- 2013/09/14 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/06/12 06:00 [medline]
AID - 10.1007/s11033-013-2745-6 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2013 Nov;40(11):6323-7. doi: 10.1007/s11033-013-2745-6.