PMID- 24078233
OWN - NLM
STAT- MEDLINE
DCOM- 20141208
LR  - 20211021
IS  - 1436-2236 (Electronic)
IS  - 1436-2228 (Linking)
VI  - 16
IP  - 3
DP  - 2014 Jun
TI  - Identification of quantitative trait loci associated with resistance to viral 
      haemorrhagic septicaemia (VHS) in turbot (Scophthalmus maximus ): a comparison 
      between bacterium, parasite and virus diseases.
PG  - 265-76
AB  - One of the main objectives of genetic breeding programs in turbot industry is to 
      reduce disease-related mortality. In the present study, a genome scan to detect 
      quantitative trait loci (QTL) affecting resistance and survival to viral 
      haemorrhagic septicaemia (VHS) was carried out. Three full-sib families with 
      approximately 90 individuals each were genotyped and evaluated by linear 
      regression and maximum likelihood approaches. In addition, a comparison between 
      QTL detected for resistance and survival time to other important bacterial and 
      parasite diseases affecting turbot (furunculosis and scuticociliatosis) was also 
      carried out. Finally, the relationship between QTL affecting resistance/survival 
      time to the virus and growth-related QTL was also evaluated. Several genomic 
      regions controlling resistance and survival time to VHS were detected. Also 
      significant associations between the evaluated traits and genotypes at particular 
      markers were identified, explaining up to 14 % of the phenotypic variance. 
      Several genomic regions controlling general and specific resistance to different 
      diseases in turbot were detected. A preliminary gene mining approach identified 
      candidate genes related to general or specific immunity. This information will be 
      valuable to develop marker-assisted selection programs and to discover candidate 
      genes related to disease resistance to improve turbot production.
FAU - Rodriguez-Ramilo, Silvia T
AU  - Rodriguez-Ramilo ST
FAU - De La Herran, Roberto
AU  - De La Herran R
FAU - Ruiz-Rejon, Carmelo
AU  - Ruiz-Rejon C
FAU - Hermida, Miguel
AU  - Hermida M
FAU - Fernandez, Carlos
AU  - Fernandez C
FAU - Pereiro, Patricia
AU  - Pereiro P
FAU - Figueras, Antonio
AU  - Figueras A
FAU - Bouza, Carmen
AU  - Bouza C
FAU - Toro, Miguel A
AU  - Toro MA
FAU - Martinez, Paulino
AU  - Martinez P
FAU - Fernandez, Jesus
AU  - Fernandez J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mar Biotechnol (NY)
JT  - Marine biotechnology (New York, N.Y.)
JID - 100892712
SB  - IM
MH  - Animals
MH  - Aquaculture/*methods
MH  - Breeding/methods
MH  - Ciliophora Infections/genetics/veterinary
MH  - Disease Resistance/*genetics
MH  - Fish Diseases/*genetics/*virology
MH  - *Flatfishes
MH  - Furunculosis/genetics
MH  - Genotype
MH  - Hemorrhagic Septicemia, Viral/*genetics
MH  - Likelihood Functions
MH  - Linear Models
MH  - Quantitative Trait Loci/*genetics
EDAT- 2013/10/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/03/11 00:00 [received]
PHST- 2013/09/12 00:00 [accepted]
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s10126-013-9544-x [doi]
PST - ppublish
SO  - Mar Biotechnol (NY). 2014 Jun;16(3):265-76. doi: 10.1007/s10126-013-9544-x.