PMID- 24078566
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20130930
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 30
IP  - 5
DP  - 2013 Oct
TI  - [Analysis of small supernumerary marker chromosome 15q11 in four infertile 
      males].
PG  - 539-43
LID - 10.3760/cma.j.issn.1003-9406.2013.05.007 [doi]
AB  - OBJECTIVE: To delineate the origins of small supernumerary marker chromosomes 
      (sSMCs) identified in 4 infertile males. METHODS: The sSMCs were analyzed with 
      combined G-banding, N-banding, multiplex ligation-dependent probe amplification 
      (MLPA), fluorescence in situ hybridization (FISH) and single nucleotide 
      polymorphisms array (SNP-array) techniques. RESULTS: G-banding analysis has 
      suggested a 46,X,-Y,+mar karyotype in all of the 4 cases. N-banding revealed that 
      all of the sSMCs have possessed two satellites located on both sides. By MLPA, 1 
      patient showed copy number gains for 15q11.2 region. SNP-array analysis suggested 
      that all had duplication for 15q11.1-q11.2 region, spanning 3.06 Mb, 0.9118 Mb, 
      1.728 Mb and 0.287 Mb, respectively. By FISH analysis, all of the sSMCs showed 
      two hybridization signals, indicating that they were dicentric chromosomes. 
      CONCLUSION: In all of the four cases, the marker chromosomes have derived from 
      chromosome 15 and were bisatellited and dicentric, which gave rise to a karyotype 
      of 47,XY,+ish,inv dup(15)(q11)(D15Z4++). sSMC 15q11 therefore may be a major 
      cause for male infertility.
FAU - Tu, Xiang-dong
AU  - Tu XD
AD  - PLA Center for Laboratory Medicine, Fuzhou General Hospital of Nanjing Military 
      Command, Fuzhou, Fujian 350025, P. R. China. Email: tuxdmed@126.com.
FAU - Cong, Xue-wen
AU  - Cong XW
FAU - Zeng, Jian
AU  - Zeng J
FAU - Zheng, De-zhu
AU  - Zheng DZ
FAU - Yan, Ai-zhen
AU  - Yan AZ
FAU - Lin, Yan-hong
AU  - Lin YH
FAU - Qiu, Li-ping
AU  - Qiu LP
FAU - Zhang, Min
AU  - Zhang M
FAU - Zhong, Fuchun
AU  - Zhong F
FAU - Lan, Fenghua
AU  - Lan F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Female
MH  - Genetic Markers
MH  - Humans
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Pregnancy
EDAT- 2013/10/01 06:00
MHDA- 2014/01/03 06:00
CRDT- 2013/10/01 06:00
PHST- 2013/10/01 06:00 [entrez]
PHST- 2013/10/01 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
AID - 940630118 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2013.05.007 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Oct;30(5):539-43. doi: 
      10.3760/cma.j.issn.1003-9406.2013.05.007.