PMID- 24079995 OWN - NLM STAT- MEDLINE DCOM- 20140625 LR - 20140714 IS - 1872-7549 (Electronic) IS - 0166-4328 (Linking) VI - 257 DP - 2013 Nov 15 TI - Type II pyrethroid deltamethrin produces antidepressant-like effects in mice. PG - 182-8 LID - S0166-4328(13)00602-5 [pii] LID - 10.1016/j.bbr.2013.09.044 [doi] AB - Pyrethroids, which are widely used insecticides with low acute toxicity in mammals, affect sodium channels in neurons. In primary culture of rat cortical neurons, the type II pyrethroid deltamethrin (DM) markedly enhances the expression of the mRNA of brain-derived neurotrophic factor (BDNF) and exerts neurotrophic effects. In this study, we investigated the antidepressant-like effect of DM in mice. The effects of DM were assessed using the forced swimming test (FST) and were compared with those of type I pyrethroid permethrin (PM). Intraperitoneal administration of DM (5 and 10mg/kg), but not of PM (10mg/kg), increased the expression of BDNF mRNA in the hippocampus. DM, but not PM, significantly decreased the immobility time in the FST, and did not affect locomotor activity and motor coordination, suggesting that DM has an antidepressant-like effect. This effect of DM was inhibited by intracerebroventricular injection of K252a, which is an inhibitor of the BDNF receptor TrkB, indicating that the antidepressant-like effects of DM are mediated by BDNF/TrkB signaling pathways. Repeated administration of DM, but not of PM, also exerted antidepressant-like effects, which were long lasting. The results of the present study suggest that DM possesses antidepressant-like properties, and may be a possible source for the development of drugs to treat neurodegenerative and psychiatric disorders including depression. CI - Copyright (c) 2013 Elsevier B.V. All rights reserved. FAU - Takasaki, Ichiro AU - Takasaki I AD - Department of Pharmacology, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan; Molecular Genetic Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: takasaki@eng.u-toyama.ac.jp. FAU - Oose, Kyohei AU - Oose K FAU - Otaki, Yuki AU - Otaki Y FAU - Ihara, Daisuke AU - Ihara D FAU - Fukuchi, Mamoru AU - Fukuchi M FAU - Tabuchi, Akiko AU - Tabuchi A FAU - Tsuneki, Hiroshi AU - Tsuneki H FAU - Tabuchi, Yoshiaki AU - Tabuchi Y FAU - Kondo, Takashi AU - Kondo T FAU - Saitoh, Akiyoshi AU - Saitoh A FAU - Yamada, Mitsuhiko AU - Yamada M FAU - Tsuda, Masaaki AU - Tsuda M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130927 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Carbazoles) RN - 0 (Enzyme Inhibitors) RN - 0 (Indole Alkaloids) RN - 0 (Nitriles) RN - 0 (Pyrethrins) RN - 2JTS8R821G (decamethrin) RN - 97161-97-2 (staurosporine aglycone) SB - IM CIN - Pharmacogenomics. 2014 Apr;15(6):735-8. PMID: 24897281 MH - Animals MH - Antidepressive Agents/chemistry/pharmacology/*therapeutic use MH - Brain-Derived Neurotrophic Factor/genetics/metabolism MH - Carbazoles/administration & dosage MH - Depression/*drug therapy/pathology MH - Disease Models, Animal MH - Dose-Response Relationship, Drug MH - Drug Administration Schedule MH - Enzyme Inhibitors/administration & dosage MH - Exploratory Behavior/drug effects MH - Gene Expression Regulation/drug effects MH - Hippocampus/drug effects/metabolism MH - Indole Alkaloids/administration & dosage MH - Locomotion/drug effects MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Nitriles/chemistry/pharmacology/*therapeutic use MH - Pyrethrins/chemistry/pharmacology/*therapeutic use MH - Swimming/psychology MH - Time Factors OTO - NOTNLM OT - Antidepressant OT - BDNF OT - DM OT - Deltamethrin OT - FST OT - Forced swimming test OT - Hippocampus OT - PM OT - Permethrin OT - brain-derived neurotrophic factor OT - deltamethrin OT - forced swimming test OT - permethrin EDAT- 2013/10/02 06:00 MHDA- 2014/06/26 06:00 CRDT- 2013/10/02 06:00 PHST- 2013/06/27 00:00 [received] PHST- 2013/09/21 00:00 [revised] PHST- 2013/09/24 00:00 [accepted] PHST- 2013/10/02 06:00 [entrez] PHST- 2013/10/02 06:00 [pubmed] PHST- 2014/06/26 06:00 [medline] AID - S0166-4328(13)00602-5 [pii] AID - 10.1016/j.bbr.2013.09.044 [doi] PST - ppublish SO - Behav Brain Res. 2013 Nov 15;257:182-8. doi: 10.1016/j.bbr.2013.09.044. Epub 2013 Sep 27.