PMID- 24080573 OWN - NLM STAT- MEDLINE DCOM- 20131125 LR - 20151119 IS - 1533-7294 (Electronic) IS - 0094-3509 (Linking) VI - 62 IP - 9 Suppl Insulin DP - 2013 Sep TI - Integrating advances in insulin into clinical practice: Advances In insulin formulations. PG - S9-17 AB - The central role of insulin in the management of patients with type 1 diabetes mellitus (T1DM) remains, nearly a century after its first use in humans. In patients with type 2 diabetes mellitus (T2DM), the role of insulin has evolved as other therapies have been introduced, with insulin now used across the spectrum of the disease. This article discusses the use of insulin in patients with T1DM or T2DM, including combined use with other agents in T2DM, with an emphasis on incretin-based therapies. In addition, new insulin products and concentrations are discussed along with their varied routes of administration. FAU - King, Allen AU - King A AD - University of California, San Francisco, CA; Diabetes Care Center, Salinas, CA, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - J Fam Pract JT - The Journal of family practice JID - 7502590 RN - 0 (Drug Combinations) RN - 0 (Hypoglycemic Agents) RN - 0 (Incretins) RN - 0 (Insulin Lispro) RN - 0 (Insulin, Long-Acting) RN - 0 (Insulins) RN - 2ZM8CX04RZ (Insulin Glargine) RN - 54Q18076QB (insulin degludec) SB - IM MH - Chemistry, Pharmaceutical MH - Diabetes Mellitus/*drug therapy MH - Drug Combinations MH - Humans MH - Hypoglycemic Agents/*administration & dosage/adverse effects/pharmacology MH - Incretins/administration & dosage/adverse effects/pharmacology MH - Insulin Glargine MH - Insulin Lispro/administration & dosage/adverse effects/pharmacology MH - Insulin, Long-Acting/administration & dosage/adverse effects/pharmacology MH - Insulins/*administration & dosage/adverse effects/pharmacology MH - Treatment Outcome EDAT- 2013/10/23 06:00 MHDA- 2013/12/16 06:00 CRDT- 2013/10/02 06:00 PHST- 2013/10/02 06:00 [entrez] PHST- 2013/10/23 06:00 [pubmed] PHST- 2013/12/16 06:00 [medline] AID - jfp_6209t [pii] PST - ppublish SO - J Fam Pract. 2013 Sep;62(9 Suppl Insulin):S9-17.