PMID- 24080829
OWN - NLM
STAT- MEDLINE
DCOM- 20140415
LR  - 20220331
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 32
IP  - 3
DP  - 2013
TI  - Akt2 deficiency is associated with anxiety and depressive behavior in mice.
PG  - 766-77
LID - 10.1159/000354478 [doi]
AB  - BACKGROUND: The economic burden associated with major depressive disorder and 
      anxiety disorders render both disorders the most common and debilitating 
      psychiatric illnesses. To date, the exact cellular and molecular mechanisms 
      underlying the pathophysiology, successful treatment and prevention of these 
      highly associated disorders have not been identified. Akt2 is a key protein in 
      the phosphatidylinositide-3 (PI3K) / glycogen synthase 3 kinase (GSK3) signaling 
      pathway, which in turn is involved in brain-derived neurotrophic factor (BDNF) 
      effects on fear memory, mood stabilisation and action of several antidepressant 
      drugs. The present study thus explored the impact of Akt2 on behaviour of mice. 
      METHODS: Behavioural studies (Open-Field, Light-Dark box, O-Maze, Forced Swimming 
      Test, Emergence Test, Object Exploration Test, Morris Water Maze, Radial Maze) 
      have been performed with Akt2 knockout mice (akt(-/-)) and corresponding wild 
      type mice (akt(+/+)). RESULTS: Anxiety and depressive behavior was significantly 
      higher in akt(-/-) than in akt(+/+) mice. The akt(-/-) mice were cognitively 
      unimpaired but displayed increased anxiety in several behavioral tests (O-Maze 
      test, Light-Dark box, Open Field test). Moreover, akt(-/-) mice spent more time 
      floating in the Forced Swimming test, which is a classical feature of 
      experimental depression. CONCLUSION: Akt2 might be a key factor in the 
      pathophysiology of depression and anxiety.
CI  - (c) 2013 S. Karger AG, Basel.
FAU - Leibrock, Christina
AU  - Leibrock C
AD  - Department of Physiology I, University of Tuebingen, Germany.
FAU - Ackermann, Teresa F
AU  - Ackermann TF
FAU - Hierlmeier, Michael
AU  - Hierlmeier M
FAU - Lang, Florian
AU  - Lang F
FAU - Borgwardt, Stefan
AU  - Borgwardt S
FAU - Lang, Undine E
AU  - Lang UE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130913
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
RN  - EC 2.7.11.1 (Akt2 protein, mouse)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Anxiety/*physiopathology
MH  - Behavior, Animal/physiology
MH  - Depression/*physiopathology
MH  - Disease Models, Animal
MH  - Mice
MH  - Mice, Knockout
MH  - Proto-Oncogene Proteins c-akt/deficiency/genetics/metabolism
EDAT- 2013/10/02 06:00
MHDA- 2014/04/16 06:00
CRDT- 2013/10/02 06:00
PHST- 2013/08/26 00:00 [accepted]
PHST- 2013/10/02 06:00 [entrez]
PHST- 2013/10/02 06:00 [pubmed]
PHST- 2014/04/16 06:00 [medline]
AID - 000354478 [pii]
AID - 10.1159/000354478 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2013;32(3):766-77. doi: 10.1159/000354478. Epub 2013 Sep 
      13.