PMID- 24081730
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20220321
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 99
IP  - 3
DP  - 2014 Mar
TI  - Gestational diabetes and type 2 diabetes in reproductive-aged women with 
      polycystic ovary syndrome.
PG  - E447-52
LID - 10.1210/jc.2013-2007 [doi]
AB  - CONTEXT: Polycystic ovary syndrome (PCOS) affects 6%-21% of women. PCOS has been 
      associated with an increased risk of dysglycemia including gestational diabetes 
      mellitus (GDM) and type 2 diabetes mellitus (T2DM). OBJECTIVE: The objective of 
      the study was to assess the prevalence of dysglycemia and the impact of obesity 
      in young reproductive-aged women with and without PCOS in a community-based 
      cohort. DESIGN: This was a cross-sectional analysis of data from a large 
      longitudinal study (the Australian Longitudinal Study on Women's Health). 
      SETTING: The setting for the study was the general community. PARTICIPANTS: Women 
      were randomly selected from the national health insurance database. Standardized 
      data collection occurred at five survey time points (years 1996, 2000, 2003, 
      2006, and 2009). Data from survey 4 (2006, n = 9145, 62% of original cohort aged 
      18-23 y) were examined for this study. MAIN OUTCOME MEASURES: Self-reported PCOS, 
      GDM, and T2DM were measured. RESULTS: In women aged 28-33 years, PCOS prevalence 
      was 5.8% [95% confidence interval (CI) 5.3%-6.4%]. The prevalence of GDM (in 
      women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS 
      and 3.8% and 0.3% in women without PCOS, respectively (P for both < .001). PCOS 
      was associated with an increased odds of GDM and T2DM. After adjusting for age, 
      body mass index, hypertension, smoking, and demographic factors, the odds of GDM 
      (odds ratio 2.1, 95% CI 1.1-3.9, P = .02) and T2DM (odds ratio 8.8, 95% CI 
      3.9-20.1, P < .001) remained increased in women reporting PCOS. CONCLUSIONS: In a 
      large community-based cohort of reproductive-aged women, PCOS was independently 
      associated with a higher risk of GDM and T2DM, independent of body mass index. 
      Aggressive screening, prevention, and management of dysglycemia is clearly 
      warranted in women with PCOS.
FAU - Joham, A E
AU  - Joham AE
AD  - Monash Centre for Health Research and Implementation, School of Public Health and 
      Preventive Medicine, (A.E.J., S.R., S.Z., L.M., H.J.T.), Monash University, and 
      Southern Health, Clayton, Victoria 3168, Australia; and The Robinson Institute 
      (L.M.), University of Adelaide, North Adelaide, SA 5006, Australia.
FAU - Ranasinha, S
AU  - Ranasinha S
FAU - Zoungas, S
AU  - Zoungas S
FAU - Moran, L
AU  - Moran L
FAU - Teede, H J
AU  - Teede HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130930
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Diabetes, Gestational/*epidemiology
MH  - Female
MH  - Humans
MH  - Obesity/complications/epidemiology
MH  - Polycystic Ovary Syndrome/complications/*epidemiology
MH  - Pregnancy
MH  - Pregnancy in Diabetics/epidemiology
MH  - Young Adult
EDAT- 2013/10/02 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/10/02 06:00
PHST- 2013/10/02 06:00 [entrez]
PHST- 2013/10/02 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - jc.2013-2007 [pii]
AID - 10.1210/jc.2013-2007 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2014 Mar;99(3):E447-52. doi: 10.1210/jc.2013-2007. Epub 
      2013 Sep 30.