PMID- 24082328
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20211021
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 10
IP  - 1
DP  - 2012
TI  - Effect of oral administration of Pheretima aspergillum (earthworm) in rats with 
      cerebral infarction induced by middle-cerebral artery occlusion.
PG  - 66-82
AB  - We investigated the curative effect of Pheretima aspergillum (earthworm, PA) on 
      rats with middle cerebral artery occlusion (MCAo). The MCAo-induced cerebral 
      infarction was established and its underlying mechanisms by counting the 
      infarction areas and evaluating the rats' neurological status. Immunostaining was 
      used to test the expression of NeuN, and glial fibrillary acidic (GFAP), S100B, 
      and brain-derived neurotrophic factor (BDNF) proteins. Our results showed that 
      oral administration of PA for two weeks to rats with MCAo successfully reduced 
      cerebral infarction areas in the cortex and striatum, and also reduced scores of 
      neurological deficit. The PA-treated MCAo rats showed greatly decreased neuronal 
      death, glial proliferation, and S100B proteins in the penumbra area of the cortex 
      and in the ischemic core area of the cortex, but BDNF did not changed. These 
      results demonstrated novel and detailed cellular mechanisms underlying the 
      neuroprotective effects of PA in MCAo rats.
FAU - Liu, Chung-Hsiang
AU  - Liu CH
AD  - Department of Neurology, China Medical University Hospital, Taichung 40402, 
      Taiwan.
FAU - Lin, Yi-Wen
AU  - Lin YW
FAU - Tang, Nou-Ying
AU  - Tang NY
FAU - Liu, Hsu-Jan
AU  - Liu HJ
FAU - Huang, Chih-Yang
AU  - Huang CY
FAU - Hsieh, Ching-Liang
AU  - Hsieh CL
LA  - eng
PT  - Journal Article
DEP - 20121001
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Biological Products)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Rbfox3 protein, rat)
RN  - 0 (S100 Calcium Binding Protein beta Subunit)
RN  - 0 (S100b protein, rat)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antigens, Nuclear/metabolism
MH  - Biological Products/pharmacology/*therapeutic use
MH  - Brain/*drug effects/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Infarction/*drug therapy/etiology/metabolism/pathology
MH  - Disease Models, Animal
MH  - Infarction, Middle Cerebral Artery/*complications
MH  - Male
MH  - Middle Cerebral Artery/pathology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - *Oligochaeta
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - S100 Calcium Binding Protein beta Subunit/metabolism
PMC - PMC3746360
OTO - NOTNLM
OT  - Cerebral infarction
OT  - Middle cerebral occlusion
OT  - Neuroprotective effect
OT  - Pheretima aspergillum
EDAT- 2012/01/01 00:00
MHDA- 2014/04/09 06:00
PMCR- 2013/10/01
CRDT- 2013/10/02 06:00
PHST- 2013/10/02 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - jAJT.v10.i1.pg66 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2012 Oct 1;10(1):66-82. eCollection 2012.