PMID- 24083422
OWN - NLM
STAT- MEDLINE
DCOM- 20140710
LR  - 20131122
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 18
IP  - 8
DP  - 2013 Dec
TI  - Prognostic implications of changes in cardiac troponin I levels in patients with 
      non-ST elevation acute coronary syndrome.
PG  - 668-72
LID - 10.3109/1354750X.2013.843023 [doi]
AB  - OBJECTIVE: Information is limited on the prognostic implications of cardiac 
      troponin I (cTnI) changes during the first days of non-ST elevation acute 
      coronary syndrome (NSTE-ACS). METHODS: High-sensitivity cTnI levels were measured 
      at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS 
      patients from the Global Use of Strategies To Open Occluded Coronary Arteries 
      (GUSTO) IV trial. RESULTS: Patients with moderately increased cTnI levels and 
      without a relevant decrease over time had a significantly raised mortality at 30 
      days and 1 year. No relevant associations between cTnI changes and recurrent 
      myocardial infarction were seen. CONCLUSION: The cTnI change is predictive for 
      subsequent mortality in selected conservatively managed NSTE-ACS patients.
FAU - Eggers, Kai M
AU  - Eggers KM
AD  - Cardiology Unit, Department of Medical Sciences, Faculty of Medicine, Uppsala 
      University , Uppsala , Sweden and.
FAU - James, Stefan
AU  - James S
FAU - Venge, Per
AU  - Venge P
FAU - Lindahl, Bertil
AU  - Lindahl B
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20131001
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Troponin I)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*physiopathology
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - Prognosis
MH  - Prospective Studies
MH  - Troponin I/*blood
EDAT- 2013/10/03 06:00
MHDA- 2014/07/11 06:00
CRDT- 2013/10/03 06:00
PHST- 2013/10/03 06:00 [entrez]
PHST- 2013/10/03 06:00 [pubmed]
PHST- 2014/07/11 06:00 [medline]
AID - 10.3109/1354750X.2013.843023 [doi]
PST - ppublish
SO  - Biomarkers. 2013 Dec;18(8):668-72. doi: 10.3109/1354750X.2013.843023. Epub 2013 
      Oct 1.