PMID- 24083631
OWN - NLM
STAT- MEDLINE
DCOM- 20140507
LR  - 20131015
IS  - 1747-4094 (Electronic)
IS  - 1747-4094 (Linking)
VI  - 6
IP  - 5
DP  - 2013 Oct
TI  - Impact of comorbidities on the treatment of chronic myeloid leukemia with 
      tyrosine-kinase inhibitors.
PG  - 563-74
LID - 10.1586/17474086.2013.837279 [doi]
AB  - The median age at diagnosis of chronic myeloid leukemia (CML) is between 60 and 
      65 years in most epidemiologic registries. Rather than age per se, a 
      comprehensive evaluation of comorbidities may describe more properly the general 
      clinical status of a patient. Tyrosine-kinase inhibitors (TKIs) have a different 
      tolerability profile, and some adverse events (AEs) are peculiar of each drug, in 
      particular, in presence of predisposing factors (comorbidities, concomitant 
      medications). This article will review the impact of comorbidities in the safety 
      and outcome of CML patients treated with TKIs. We will explore how the 
      comorbidity status may be considered, together with CML-related factors, in the 
      selection of the TKI in order to optimize treatment.
FAU - Gugliotta, Gabriele
AU  - Gugliotta G
AD  - Department of Experimental, Diagnostic and Specialty Medicine, S.Orsola-Malpighi 
      Hospital, University of Bologna, Institute of Hematology "L. e A. Seragnoli", 
      Bologna, Italy.
FAU - Castagnetti, Fausto
AU  - Castagnetti F
FAU - Fogli, Miriam
AU  - Fogli M
FAU - Cavo, Michele
AU  - Cavo M
FAU - Baccarani, Michele
AU  - Baccarani M
FAU - Rosti, Gianantonio
AU  - Rosti G
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131002
PL  - England
TA  - Expert Rev Hematol
JT  - Expert review of hematology
JID - 101485942
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protein Kinase Inhibitors)
SB  - IM
MH  - Antineoplastic Agents/adverse effects/*therapeutic use
MH  - Comorbidity
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy
MH  - Protein Kinase Inhibitors/adverse effects/*therapeutic use
EDAT- 2013/10/03 06:00
MHDA- 2014/05/08 06:00
CRDT- 2013/10/03 06:00
PHST- 2013/10/03 06:00 [entrez]
PHST- 2013/10/03 06:00 [pubmed]
PHST- 2014/05/08 06:00 [medline]
AID - 10.1586/17474086.2013.837279 [doi]
PST - ppublish
SO  - Expert Rev Hematol. 2013 Oct;6(5):563-74. doi: 10.1586/17474086.2013.837279. Epub 
      2013 Oct 2.