PMID- 24084046
OWN - NLM
STAT- MEDLINE
DCOM- 20140114
LR  - 20131101
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 93
IP  - 21
DP  - 2013 Nov 13
TI  - Chronic alcohol consumption, type 2 diabetes mellitus, insulin-like growth 
      factor-I (IGF-I), and growth hormone (GH) in ethanol-treated diabetic rats.
PG  - 778-82
LID - S0024-3205(13)00553-5 [pii]
LID - 10.1016/j.lfs.2013.09.018 [doi]
AB  - AIMS: Alcohol has deleterious influences on glucose metabolism which may 
      contribute to the development of type 2 diabetes mellitus (T2DM). Insulin-like 
      growth factor I (IGF-I) and growth hormone (GH), which interact with insulin to 
      modulate metabolic control, have been shown to be related to impaired glucose 
      tolerance. This study was conducted to assess the possibility that altered 
      circulating IGF-I and GH levels contribute to the exacerbation of T2DM by alcohol 
      use in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and 
      non-diabetic Long-Evans Tokushima Otsuka (LETO) rats. MAIN METHOD: OLETF rats 
      were pair-fed a Lieber-DeCarli Regular Ethanol diet and LETO rats were pair-fed a 
      control diet for 6 weeks. At 6 weeks, an Intraperitoneal Glucose Tolerance Test 
      (IP-GTT) was performed and IGF-I and GH levels were evaluated. KEY FINDINGS: 
      Prior to an IP-GTT, OLETF-Ethanol (O-E) group had significantly a decrease in the 
      mean glucose levels compared to OLETF-Control (O-C) group. At 120 min post 
      IP-GTT, the O-E group had significantly an increase in the mean glucose levels 
      compared to O-C group. The serum IGF-I levels were significantly lower and the 
      serum GH levels were significantly higher in the O-E group than in L-C group. 
      SIGNIFICANCE: These results suggest that IGF-I and GH are prominent in defining 
      the risk and development of T2DM, and may be adversely affected by heavy alcohol 
      use, possibly mediating its diabetogenic effects. Thus, the overall glucose 
      intolerance in the setting of alcoholism may be attributable to inappropriate 
      alteration of IGF-I and GH levels.
CI  - (c) 2013. Published by Elsevier Inc. All rights reserved.
FAU - Kim, Soo-Jeong
AU  - Kim SJ
AD  - Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of 
      Korea College of Medicine, Seoul, Republic of Korea.
FAU - Ju, Anes
AU  - Ju A
FAU - Lim, Seul-Gi
AU  - Lim SG
FAU - Kim, Dai-Jin
AU  - Kim DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130929
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 3K9958V90M (Ethanol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Alcohol Drinking/blood/*metabolism
MH  - Animals
MH  - Blood Glucose/*drug effects/metabolism
MH  - Body Weight/drug effects
MH  - Diabetes Mellitus, Type 2/blood/*metabolism
MH  - Ethanol/*pharmacology
MH  - Glucose Intolerance
MH  - Glucose Tolerance Test
MH  - Growth Hormone/*blood
MH  - Insulin/blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred OLETF
OTO - NOTNLM
OT  - Alcohol use
OT  - Glucose tolerance
OT  - IGF-I
OT  - LETO rats
OT  - OLETF rats
EDAT- 2013/10/03 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/10/03 06:00
PHST- 2013/05/31 00:00 [received]
PHST- 2013/08/27 00:00 [revised]
PHST- 2013/09/19 00:00 [accepted]
PHST- 2013/10/03 06:00 [entrez]
PHST- 2013/10/03 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - S0024-3205(13)00553-5 [pii]
AID - 10.1016/j.lfs.2013.09.018 [doi]
PST - ppublish
SO  - Life Sci. 2013 Nov 13;93(21):778-82. doi: 10.1016/j.lfs.2013.09.018. Epub 2013 
      Sep 29.