PMID- 24084089
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20220321
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 54
IP  - 12
DP  - 2013 Nov 15
TI  - Fully automatic software for retinal thickness in eyes with diabetic macular 
      edema from images acquired by cirrus and spectralis systems.
PG  - 7595-602
LID - 10.1167/iovs.13-11762 [doi]
AB  - PURPOSE: To determine whether a novel automatic segmentation program, the Duke 
      Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied 
      to spectral-domain optical coherence tomography (SD-OCT) images obtained from 
      different commercially available SD-OCT in eyes with diabetic macular edema 
      (DME). METHODS: A novel segmentation framework was used to segment the retina, 
      inner retinal pigment epithelium, and Bruch's membrane on images from eyes with 
      DME acquired by one of two SD-OCT systems, Spectralis or Cirrus high definition 
      (HD)-OCT. Thickness data obtained by the DOCTRAP software were compared with 
      those produced by Spectralis and Cirrus. Measurement agreement and its dependence 
      were assessed using intraclass correlation (ICC). RESULTS: A total of 40 SD-OCT 
      scans from 20 subjects for each machine were included in the analysis. 
      Spectralis: the mean thickness in the 1-mm central area determined by DOCTRAP and 
      Spectralis was 463.8 +/- 107.5 mum and 467.0 +/- 108.1 mum, respectively (ICC, 0.999). 
      There was also a high level agreement in surrounding areas (out to 3 mm). Cirrus: 
      the mean thickness in the 1-mm central area was 440.8 +/- 183.4 mum and 442.7 +/- 
      182.4 mum by DOCTRAP and Cirrus, respectively (ICC, 0.999). The thickness 
      agreement in surrounding areas (out to 3 mm) was more variable due to Cirrus 
      segmentation errors in one subject (ICC, 0.734-0.999). After manual correction of 
      the errors, there was a high level of thickness agreement in surrounding areas 
      (ICC, 0.997-1.000). CONCLUSIONS: The DOCTRAP may be useful to compare retinal 
      thicknesses in eyes with DME across OCT platforms.
FAU - Lee, Joo Yong
AU  - Lee JY
AD  - Department of Ophthalmology, Duke University Medical Center, Durham, North 
      Carolina.
FAU - Chiu, Stephanie J
AU  - Chiu SJ
FAU - Srinivasan, Pratul P
AU  - Srinivasan PP
FAU - Izatt, Joseph A
AU  - Izatt JA
FAU - Toth, Cynthia A
AU  - Toth CA
FAU - Farsiu, Sina
AU  - Farsiu S
FAU - Jaffe, Glenn J
AU  - Jaffe GJ
LA  - eng
GR  - P30 EY005722/EY/NEI NIH HHS/United States
GR  - R01 EY022691/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20131115
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Algorithms
MH  - Diabetic Retinopathy/*diagnosis
MH  - Humans
MH  - Image Processing, Computer-Assisted/*instrumentation
MH  - Macular Edema/*diagnosis
MH  - Organ Size
MH  - Retina/*pathology
MH  - Retinal Photoreceptor Cell Inner Segment/pathology
MH  - Retinal Photoreceptor Cell Outer Segment/pathology
MH  - Retinal Pigment Epithelium/pathology
MH  - *Software
MH  - Tomography, Optical Coherence/instrumentation/*methods
PMC - PMC4428560
OTO - NOTNLM
OT  - diabetic macular edema (DME)
OT  - segmentation
OT  - spectral-domain optical coherence tomography (SD-OCT)
EDAT- 2013/10/03 06:00
MHDA- 2014/01/25 06:00
PMCR- 2014/05/01
CRDT- 2013/10/03 06:00
PHST- 2013/10/03 06:00 [entrez]
PHST- 2013/10/03 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - iovs.13-11762 [pii]
AID - 10.1167/iovs.13-11762 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2013 Nov 15;54(12):7595-602. doi: 
      10.1167/iovs.13-11762.