PMID- 24085471
OWN - NLM
STAT- MEDLINE
DCOM- 20150522
LR  - 20211021
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 29
IP  - 5
DP  - 2014 Sep
TI  - Isolated left ventricular noncompaction: clinical profile and prognosis in 106 
      adult patients.
PG  - 645-52
LID - 10.1007/s00380-013-0409-z [doi]
AB  - This study was undertaken to evaluate the clinical course of isolated left 
      ventricular noncompaction (ILVNC) and to identify the predictors for adverse 
      outcomes in an adult cohort with ILVNC. Between March 2003 and April 2012, 106 
      adult patients diagnosed with ILVNC at Fuwai Hospital were included in this 
      study. The medical history, electrocardiograms, and echocardiograms of these 
      patients were retrospectively analyzed by chart review. Of these patients, 64 (60 
      %) were in New York Heart Association (NYHA) functional class III/IV and 84 (79 
      %) had systolic dysfunction (left ventricular ejection fraction (LVEF) <50 %). 
      During a follow-up of 2.9 +/- 2.1 years, 28 (26 %) patients died or underwent heart 
      transplantation. The annual incidence of death or transplantation was 9.1 %. The 
      determinants of death or heart transplantation included NYHA functional class 
      III/IV (hazard ratio (HR) 4.52; 95 % confidence interval (CI) 1.57-13.04; P = 
      0.005), decreased left ventricular ejection fraction (HR 0.94; 95 % CI 0.90-0.97; 
      P = 0.001), dilated left ventricular end-diastolic diameter (HR, 1.06; 95 % CI, 
      1.02-1.09; P = 0.001), increased left atrial diameter (HR 1.08; 95 % CI 
      1.03-1.14; P = 0.001), reduced systolic blood pressure (HR 0.96; 95 % CI 
      0.94-0.99; P = 0.003), the presence of pulmonary hypertension (HR 3.50; 95 % CI 
      1.63-7.51; P = 0.001), and right bundle branch block (HR 7.79; 95 % CI 
      2.56-23.76; P < 0.001). In conclusion, this study demonstrates that ILVNC is 
      related to a high incidence of death or heart transplantation. Advanced heart 
      failure, a dilated left heart with systolic dysfunction, reduced systolic blood 
      pressure, pulmonary hypertension, and right bundle branch block predict adverse 
      outcomes of ILVNC.
FAU - Tian, Tao
AU  - Tian T
AD  - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, No. 167 Beilishi Road, Beijing, 
      100037, People's Republic of China, tiantaophd@163.com.
FAU - Liu, Yaxin
AU  - Liu Y
FAU - Gao, Linggen
AU  - Gao L
FAU - Wang, Jizheng
AU  - Wang J
FAU - Sun, Kai
AU  - Sun K
FAU - Zou, Yubao
AU  - Zou Y
FAU - Wang, Linping
AU  - Wang L
FAU - Zhang, Lin
AU  - Zhang L
FAU - Li, Yuehua
AU  - Li Y
FAU - Xiao, Yan
AU  - Xiao Y
FAU - Song, Lei
AU  - Song L
FAU - Zhou, Xianliang
AU  - Zhou X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131002
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arterial Pressure
MH  - Bundle-Branch Block/diagnosis/physiopathology
MH  - China
MH  - Disease Progression
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/diagnosis/physiopathology
MH  - Heart Transplantation
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/physiopathology
MH  - Hypertrophy, Left Ventricular/diagnosis/physiopathology
MH  - Isolated Noncompaction of the Ventricular 
      Myocardium/*diagnosis/mortality/physiopathology/therapy
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Dysfunction, Left/diagnosis/physiopathology
MH  - Ventricular Function, Left
MH  - Young Adult
EDAT- 2013/10/03 06:00
MHDA- 2015/05/23 06:00
CRDT- 2013/10/03 06:00
PHST- 2013/06/09 00:00 [received]
PHST- 2013/08/30 00:00 [accepted]
PHST- 2013/10/03 06:00 [entrez]
PHST- 2013/10/03 06:00 [pubmed]
PHST- 2015/05/23 06:00 [medline]
AID - 10.1007/s00380-013-0409-z [doi]
PST - ppublish
SO  - Heart Vessels. 2014 Sep;29(5):645-52. doi: 10.1007/s00380-013-0409-z. Epub 2013 
      Oct 2.